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- W2013074077 abstract "Interleukin-1-beta (IL-1beta) can promote inflammation by up-regulating vascular adhesion molecules and inhibit inflammation by activating the hypothalamic-pituitary-adrenal (HPA) axis to produce anti-inflammatory glucocorticoids. In this study, chronic morphine was shown to suppress IL-1beta-induction of corticotropin releasing factor (CRF) mRNA and plasma corticosterone levels. Leukocyte-endothelial adhesion (LEA) in rat mesenteric venules increased during IL-1beta- and FMLP-induced inflammation. Chronic morphine potentiated the LEA response to either IL-1beta or FMLP alone, and greatly enhanced LEA in response to combined IL-1beta and FMLP. Thus, it appears that chronic morphine exposure may promote a potentially damaging inflammatory reaction by disrupting the balance between IL-1beta-mediated local inflammation and the anti-inflammatory effects of the HPA axis." @default.
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- W2013074077 date "2001-08-30" @default.
- W2013074077 modified "2023-09-27" @default.
- W2013074077 title "Chronic morphine potentiates the inflammatory response by disrupting interleukin-1β modulation of the hypothalamic–pituitary–adrenal axis" @default.
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- W2013074077 doi "https://doi.org/10.1016/s0165-5728(01)00337-x" @default.
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