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- W2013075573 abstract "To describe prognosis for specific cohorts of men with SCO undergoing mTESE. Retrospective clinical study. A review was performed of the last 1494 patients with nonobstructive azoospermia (AZ), confirmed by analysis of 2 centrifuged semen samples, who underwent mTESE at a single center after a sample obtained on the day of planned mTESE confirmed AZ. Patients with complete AZFa or AZFb microdeletions were excluded. Testis volume was measured by physical examination with an orchidometer, and was averaged in patients undergoing bilateral mTESE. FSH was obtained within 2 months prior to mTESE. Only patients with 100% SCO on diagnostic biopsy were included. Differences in sperm retrieval rates (SRR) were compared using a chi-square analysis. 670 patients with mean age 34.1 ± 6.5 years were analyzed. Mean testis volume was 8.2 ± 4.8 cc. Mean FSH was 25.4 ± 14.6 mU/mL. Overall SRR was 43.6%, with a clinical pregnancy rate of 45.6% and live birth rate of 25.4% among those with successful retrieval. SRR was significantly higher among patients with testis volume <15cc compared to ≥ 15cc (45.6% vs 32.4%, p = 0.03) and for patients with FSH ≥ 15 mU/mL compared to FSH <15 mU/mL (considering men with both low and normal volume testes). SRR stratified by FSH levels are presented in the table. Men with FSH of 10-15 mU/mL and normal testes had the worst prognosis, with an SRR of only 5.9%.Tabled 1Testis Vol <15ccTestis Vol ≥ 15ccFSH <15FSH ≥ 15p valueFSH <10FSH 10-15FSH ≥ 15p valuen114482121745SRR (%)34.248.80.00533.35.942.20.024 Open table in a new tab Although SCO on diagnostic biopsy can allow sperm retrieval with mTESE at our center, a subset of men with intermediate FSH levels and larger testis volume have a very poor prognosis for sperm retrieval. These men appear to have less heterogeneity within the testis, with a uniform pattern of SCO seen on microdissection." @default.
- W2013075573 created "2016-06-24" @default.
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- W2013075573 date "2013-09-01" @default.
- W2013075573 modified "2023-09-29" @default.
- W2013075573 title "A subset of men with sertoli cell only pattern (SCO) have poor outcomes, even with microdissection testicular sperm extraction (mTESE)" @default.
- W2013075573 doi "https://doi.org/10.1016/j.fertnstert.2013.07.545" @default.
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