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• W2013076099 abstract "AMPA receptors (AMPARs) have been demonstrated to be an important therapeutic CNS target. A series of substituted benzotriazinone and benzopyrimidinone derivatives were prepared with the aim to improve in vivo activity over the previously reported bis-benzoxazinone based AMPAKINE® series from our laboratory. These compounds were shown to be potent, positive allosteric AMPAR modulators that have better in vivo activity and improved metabolic stability over the analogous benzoxazinone derivatives." @default.
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• W2013076099 date "2011-10-01" @default.
• W2013076099 modified "2023-10-16" @default.
• W2013076099 title "Benzotriazinone and benzopyrimidinone derivatives as potent positive allosteric AMPA receptor modulators" @default.
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• W2013076099 doi "https://doi.org/10.1016/j.bmcl.2011.07.098" @default.
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