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- W2013079907 abstract "Investigation of the toxic and antitumor effects of 10 chemotherapeutic agents and hyperbaric oxygen was undertaken with 5 tumors in 9 rodent species. Pentobarbital sodium greatly enhanced the toxicity of hyperbaric oxygen in mice. D-54 naponate, a dihydrotriazine, was significantly more toxic when administered with hyperbaric oxygen; the toxicity of other drugs tested was not altered significantly by high oxygen pressure. Prolongation of survival time and inhibition of tumor growth by drug alone was enhanced by a combination of hyperbaric oxygen and OMF-59, a cyclophosphamide congener. None of the other drugs studied showed significant increase in antitumor activity with hyperbaric oxygen. In general, the results show little enhancement of antitumor effect by hyperbaric oxygen; however, the specific techniques of oxygen administration and the types of animal, drug, and tumor tested are all critical determinants of results." @default.
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- W2013079907 date "1966-07-01" @default.
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- W2013079907 title "Effects of antitumor agents and hyperbaric oxygen in normal and tumor-bearing rodents" @default.
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- W2013079907 doi "https://doi.org/10.1002/1097-0142(196607)19:7<1019::aid-cncr2820190717>3.0.co;2-v" @default.
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