FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013081267> ?p ?o ?g. }

• W2013081267 endingPage "321" @default.
• W2013081267 startingPage "313" @default.
• W2013081267 abstract "Background: The modulating effects of the multiple sclerosis (MS) risk-associated single-nucleotide polymorphisms (SNPs) on MS clinical course are not well established. Objectives: The objective of this paper is to investigate whether known MS risk-associated SNPs were associated with clinical course, and whether these SNPs modified the 25(OH)D-relapse association. Methods: Using a prospective cohort of 141 participants with relapsing–remitting MS and genotype data followed between 2002 and 2005, genotype-vitamin D interactions and the genetic predictors of relapse were assessed using survival analysis, and genetic predictors of 25(OH)D and disability progression were evaluated by multilevel mixed-effects linear regression. Results: While no SNP reached statistical significance after multiple testing, five SNPs were associated with relapse, with significant cumulative genotype risk effects and two demonstrated significant allele dose-response. Two SNPs altered the 25(OH)D-relapse association with significant allele dose-response. Five SNPs modified levels of 25(OH)D, with significant cumulative genotype ‘risk’ effect, and three demonstrated significant allele dose-response. We found no consistent evidence for an association between any SNPs and disability. Conclusions: Our study provides evidence for an association between known MS risk-associated SNPs and relapse. Our findings indicate gene-environment interactions may be an important mechanism on MS clinical course, and provide support for the role of vitamin D in MS relapse." @default.
• W2013081267 created "2016-06-24" @default.
• W2013081267 creator A5035626172 @default.
• W2013081267 creator A5039829859 @default.
• W2013081267 creator A5042142014 @default.
• W2013081267 creator A5067070663 @default.
• W2013081267 creator A5071467218 @default.
• W2013081267 creator A5073883447 @default.
• W2013081267 creator A5075028539 @default.
• W2013081267 creator A5091688246 @default.
• W2013081267 date "2013-07-25" @default.
• W2013081267 modified "2023-10-18" @default.
• W2013081267 title "Association between multiple sclerosis risk-associated SNPs and relapse and disability – a prospective cohort study" @default.
• W2013081267 cites W1967239133 @default.
• W2013081267 cites W1982303250 @default.
• W2013081267 cites W1999427630 @default.
• W2013081267 cites W2016311557 @default.
• W2013081267 cites W2022167363 @default.
• W2013081267 cites W2040547343 @default.
• W2013081267 cites W2054475366 @default.
• W2013081267 cites W2059542829 @default.
• W2013081267 cites W2061278328 @default.
• W2013081267 cites W2066626859 @default.
• W2013081267 cites W2066668961 @default.
• W2013081267 cites W2075112416 @default.
• W2013081267 cites W2080511279 @default.
• W2013081267 cites W2092659219 @default.
• W2013081267 cites W2094205468 @default.
• W2013081267 cites W2094237226 @default.
• W2013081267 cites W2095839641 @default.
• W2013081267 cites W2100784533 @default.
• W2013081267 cites W2103649136 @default.
• W2013081267 cites W2105490558 @default.
• W2013081267 cites W2109978145 @default.
• W2013081267 cites W2110228129 @default.
• W2013081267 cites W2111536363 @default.
• W2013081267 cites W2132499228 @default.
• W2013081267 cites W2138258120 @default.
• W2013081267 cites W2139227027 @default.
• W2013081267 cites W2145159920 @default.
• W2013081267 cites W2159945795 @default.
• W2013081267 cites W2161633633 @default.
• W2013081267 cites W2161977215 @default.
• W2013081267 cites W2167022428 @default.
• W2013081267 cites W4250145052 @default.
• W2013081267 doi "https://doi.org/10.1177/1352458513496882" @default.
• W2013081267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23886828" @default.
• W2013081267 hasPublicationYear "2013" @default.
• W2013081267 type Work @default.
• W2013081267 sameAs 2013081267 @default.
• W2013081267 citedByCount "25" @default.
• W2013081267 countsByYear W20130812672014 @default.
• W2013081267 countsByYear W20130812672015 @default.
• W2013081267 countsByYear W20130812672016 @default.
• W2013081267 countsByYear W20130812672017 @default.
• W2013081267 countsByYear W20130812672018 @default.
• W2013081267 countsByYear W20130812672019 @default.
• W2013081267 countsByYear W20130812672020 @default.
• W2013081267 countsByYear W20130812672021 @default.
• W2013081267 countsByYear W20130812672022 @default.
• W2013081267 countsByYear W20130812672023 @default.
• W2013081267 crossrefType "journal-article" @default.
• W2013081267 hasAuthorship W2013081267A5035626172 @default.
• W2013081267 hasAuthorship W2013081267A5039829859 @default.
• W2013081267 hasAuthorship W2013081267A5042142014 @default.
• W2013081267 hasAuthorship W2013081267A5067070663 @default.
• W2013081267 hasAuthorship W2013081267A5071467218 @default.
• W2013081267 hasAuthorship W2013081267A5073883447 @default.
• W2013081267 hasAuthorship W2013081267A5075028539 @default.
• W2013081267 hasAuthorship W2013081267A5091688246 @default.
• W2013081267 hasConcept C104317684 @default.
• W2013081267 hasConcept C126322002 @default.
• W2013081267 hasConcept C135763542 @default.
• W2013081267 hasConcept C139275648 @default.
• W2013081267 hasConcept C143998085 @default.
• W2013081267 hasConcept C153209595 @default.
• W2013081267 hasConcept C180754005 @default.
• W2013081267 hasConcept C186413461 @default.
• W2013081267 hasConcept C188816634 @default.
• W2013081267 hasConcept C203014093 @default.
• W2013081267 hasConcept C2780640218 @default.
• W2013081267 hasConcept C54355233 @default.
• W2013081267 hasConcept C71924100 @default.
• W2013081267 hasConcept C72563966 @default.
• W2013081267 hasConcept C86803240 @default.
• W2013081267 hasConceptScore W2013081267C104317684 @default.
• W2013081267 hasConceptScore W2013081267C126322002 @default.
• W2013081267 hasConceptScore W2013081267C135763542 @default.
• W2013081267 hasConceptScore W2013081267C139275648 @default.
• W2013081267 hasConceptScore W2013081267C143998085 @default.
• W2013081267 hasConceptScore W2013081267C153209595 @default.
• W2013081267 hasConceptScore W2013081267C180754005 @default.
• W2013081267 hasConceptScore W2013081267C186413461 @default.
• W2013081267 hasConceptScore W2013081267C188816634 @default.
• W2013081267 hasConceptScore W2013081267C203014093 @default.
• W2013081267 hasConceptScore W2013081267C2780640218 @default.
• W2013081267 hasConceptScore W2013081267C54355233 @default.
• W2013081267 hasConceptScore W2013081267C71924100 @default.

• next