FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013082085> ?p ?o ?g. }

• W2013082085 endingPage "578" @default.
• W2013082085 startingPage "569" @default.
• W2013082085 abstract "The data here reported show that the gene expression of the glycoprotein Po and of the myelin basic protein, the major components of myelin in the peripheral nervous system, dramatically decreases with ageing in the sciatic nerve of normal male rats. A one-month treatment with dihydroprogesterone, the 5alpha-reduced derivative of progesterone, is able to partially restore the fall in Po gene expression occurring in the sciatic nerve of aged male rats, without significantly modifying the gene expression of the myelin basic protein. In cultures of neonatal Schwann cells (the peripheral nervous system elements involved in the synthesis of myelin), the addition of progesterone and of dihydroprogesterone significantly increases Po gene expression; the 3alpha-reduced metabolite of dihydroprogesterone, tetrahydroprogesterone proved to be even more effective. These data suggest that the effect of progesterone is linked to its conversion into dihydroprogesterone and especially into tetrahydroprogesterone, since Schwann cells possess the 5alpha-reductase-3alpha-hydroxysteroid dehydrogenase system. The data provide the first demonstration that ageing decreases the gene expression of two major components of the peripheral myelin in the sciatic nerve; they also show that this phenomenon may be partially reversed by progesterone derivatives, which might act by stimulating Po gene expression in the Schwann cells." @default.
• W2013082085 created "2016-06-24" @default.
• W2013082085 creator A5002963265 @default.
• W2013082085 creator A5005948227 @default.
• W2013082085 creator A5008522126 @default.
• W2013082085 creator A5064487157 @default.
• W2013082085 creator A5088952771 @default.
• W2013082085 date "1998-04-01" @default.
• W2013082085 modified "2023-09-27" @default.
• W2013082085 title "Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives" @default.
• W2013082085 cites W1503400677 @default.
• W2013082085 cites W1967272890 @default.
• W2013082085 cites W1978190462 @default.
• W2013082085 cites W1979454972 @default.
• W2013082085 cites W1984214481 @default.
• W2013082085 cites W1993286333 @default.
• W2013082085 cites W2004827915 @default.
• W2013082085 cites W2006296015 @default.
• W2013082085 cites W2011866525 @default.
• W2013082085 cites W2014370769 @default.
• W2013082085 cites W2015377170 @default.
• W2013082085 cites W2017699870 @default.
• W2013082085 cites W2018217692 @default.
• W2013082085 cites W2027866675 @default.
• W2013082085 cites W2032844562 @default.
• W2013082085 cites W2034325225 @default.
• W2013082085 cites W2034386955 @default.
• W2013082085 cites W2037691396 @default.
• W2013082085 cites W2052564014 @default.
• W2013082085 cites W2057535584 @default.
• W2013082085 cites W2063439191 @default.
• W2013082085 cites W2064206062 @default.
• W2013082085 cites W2067851328 @default.
• W2013082085 cites W2077888730 @default.
• W2013082085 cites W2081768334 @default.
• W2013082085 cites W2084313287 @default.
• W2013082085 cites W2085880342 @default.
• W2013082085 cites W2087022458 @default.
• W2013082085 cites W2105653434 @default.
• W2013082085 cites W2117731766 @default.
• W2013082085 cites W2322269681 @default.
• W2013082085 cites W2323128415 @default.
• W2013082085 cites W2330595203 @default.
• W2013082085 cites W2592846019 @default.
• W2013082085 cites W2885040638 @default.
• W2013082085 cites W4250159520 @default.
• W2013082085 cites W4293247451 @default.
• W2013082085 cites W4294216491 @default.
• W2013082085 doi "https://doi.org/10.1016/s0306-4522(97)00628-3" @default.
• W2013082085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9622253" @default.
• W2013082085 hasPublicationYear "1998" @default.
• W2013082085 type Work @default.
• W2013082085 sameAs 2013082085 @default.
• W2013082085 citedByCount "104" @default.
• W2013082085 countsByYear W20130820852012 @default.
• W2013082085 countsByYear W20130820852013 @default.
• W2013082085 countsByYear W20130820852014 @default.
• W2013082085 countsByYear W20130820852015 @default.
• W2013082085 countsByYear W20130820852016 @default.
• W2013082085 countsByYear W20130820852017 @default.
• W2013082085 countsByYear W20130820852018 @default.
• W2013082085 countsByYear W20130820852019 @default.
• W2013082085 countsByYear W20130820852020 @default.
• W2013082085 crossrefType "journal-article" @default.
• W2013082085 hasAuthorship W2013082085A5002963265 @default.
• W2013082085 hasAuthorship W2013082085A5005948227 @default.
• W2013082085 hasAuthorship W2013082085A5008522126 @default.
• W2013082085 hasAuthorship W2013082085A5064487157 @default.
• W2013082085 hasAuthorship W2013082085A5088952771 @default.
• W2013082085 hasConcept C104317684 @default.
• W2013082085 hasConcept C126322002 @default.
• W2013082085 hasConcept C134018914 @default.
• W2013082085 hasConcept C150194340 @default.
• W2013082085 hasConcept C185592680 @default.
• W2013082085 hasConcept C2778609137 @default.
• W2013082085 hasConcept C2780876595 @default.
• W2013082085 hasConcept C2781149210 @default.
• W2013082085 hasConcept C529278444 @default.
• W2013082085 hasConcept C545314008 @default.
• W2013082085 hasConcept C55493867 @default.
• W2013082085 hasConcept C71924100 @default.
• W2013082085 hasConcept C86803240 @default.
• W2013082085 hasConceptScore W2013082085C104317684 @default.
• W2013082085 hasConceptScore W2013082085C126322002 @default.
• W2013082085 hasConceptScore W2013082085C134018914 @default.
• W2013082085 hasConceptScore W2013082085C150194340 @default.
• W2013082085 hasConceptScore W2013082085C185592680 @default.
• W2013082085 hasConceptScore W2013082085C2778609137 @default.
• W2013082085 hasConceptScore W2013082085C2780876595 @default.
• W2013082085 hasConceptScore W2013082085C2781149210 @default.
• W2013082085 hasConceptScore W2013082085C529278444 @default.
• W2013082085 hasConceptScore W2013082085C545314008 @default.
• W2013082085 hasConceptScore W2013082085C55493867 @default.
• W2013082085 hasConceptScore W2013082085C71924100 @default.
• W2013082085 hasConceptScore W2013082085C86803240 @default.
• W2013082085 hasIssue "2" @default.
• W2013082085 hasLocation W20130820851 @default.
• W2013082085 hasLocation W20130820852 @default.

• next