Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013084549> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2013084549 endingPage "1072" @default.
- W2013084549 startingPage "1066" @default.
- W2013084549 abstract "Diaspirin crosslinked hemoglobin (DCLHb) is a cell-free hemoglobin derived from human erythrocytes. DCLHb has been shown to improve blood flow to vital organs in healthy and septic animals. In this study, we determined the efficacy of DCLHb by comparing its effect on systemic O2 uptake to freshly stored and aged red blood cells (RBCs) in septic rats. Twenty-four hours after induction of sepsis by cecal ligation and perforation, O2 supply dependency was created by isovolemic hemodilution with rat plasma. In O2 supply dependency, rats were randomized to receive an exchange transfusion of 7.5 ml “fresh” RBCs (stored < 6 d; Hct: 70%), “fresh” diluted RBCs (stored < 6 d; Hct: 30%), “old” RBCs (stored 28 to 35 d; Hct: 70%), or DCLHb (Hb: 100 g/L). We found, that survival following O2 supply dependency and transfusion with old RBCs was poor (33% versus 91.7% in the other groups; p < 0.01), precluding further analysis of post-transfusion data from this group. Systemic O2 uptake increased in all remaining groups (p < 0.001), while systemic O2 delivery increased with “fresh” RBCs (p < 0.0001) and “fresh” diluted RBCs (p < 0.05) but not with DCLHb. Systemic O2 extraction increased with DCLHb as compared to baseline (p < 0.05) and to the other groups (p < 0.0001). Improved tissue oxygenation was associated with an increase in blood pressure and a fall in arterial lactate in all groups. We conclude that transfusion of DCLHb or “fresh” RBCs was efficacious at increasing systemic O2 uptake in O2 supply–dependent, septic rats." @default.
- W2013084549 created "2016-06-24" @default.
- W2013084549 creator A5031981118 @default.
- W2013084549 creator A5063775207 @default.
- W2013084549 creator A5082823626 @default.
- W2013084549 creator A5089033148 @default.
- W2013084549 date "1997-10-01" @default.
- W2013084549 modified "2023-10-17" @default.
- W2013084549 title "Diaspirin Crosslinked Hemoglobin Improves Systemic Oxygen Uptake in Oxygen Supply–dependent Septic Rats" @default.
- W2013084549 cites W1265402612 @default.
- W2013084549 cites W1494977501 @default.
- W2013084549 cites W1554966787 @default.
- W2013084549 cites W184229330 @default.
- W2013084549 cites W1956622349 @default.
- W2013084549 cites W1977342284 @default.
- W2013084549 cites W2016573557 @default.
- W2013084549 cites W2019013081 @default.
- W2013084549 cites W2043420263 @default.
- W2013084549 cites W2043769632 @default.
- W2013084549 cites W2043987331 @default.
- W2013084549 cites W2057703018 @default.
- W2013084549 cites W2069700927 @default.
- W2013084549 cites W2085041868 @default.
- W2013084549 cites W2085200563 @default.
- W2013084549 cites W2086406624 @default.
- W2013084549 cites W2092547186 @default.
- W2013084549 cites W2114994858 @default.
- W2013084549 cites W2126601359 @default.
- W2013084549 cites W2178915660 @default.
- W2013084549 cites W2238343100 @default.
- W2013084549 cites W2398405050 @default.
- W2013084549 cites W2411982971 @default.
- W2013084549 cites W90376605 @default.
- W2013084549 doi "https://doi.org/10.1164/ajrccm.156.4.9609097" @default.
- W2013084549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9351604" @default.
- W2013084549 hasPublicationYear "1997" @default.
- W2013084549 type Work @default.
- W2013084549 sameAs 2013084549 @default.
- W2013084549 citedByCount "69" @default.
- W2013084549 countsByYear W20130845492015 @default.
- W2013084549 countsByYear W20130845492021 @default.
- W2013084549 crossrefType "journal-article" @default.
- W2013084549 hasAuthorship W2013084549A5031981118 @default.
- W2013084549 hasAuthorship W2013084549A5063775207 @default.
- W2013084549 hasAuthorship W2013084549A5082823626 @default.
- W2013084549 hasAuthorship W2013084549A5089033148 @default.
- W2013084549 hasConcept C126322002 @default.
- W2013084549 hasConcept C2776557347 @default.
- W2013084549 hasConcept C2778337571 @default.
- W2013084549 hasConcept C2778384902 @default.
- W2013084549 hasConcept C2778917026 @default.
- W2013084549 hasConcept C42219234 @default.
- W2013084549 hasConcept C70289976 @default.
- W2013084549 hasConcept C71924100 @default.
- W2013084549 hasConceptScore W2013084549C126322002 @default.
- W2013084549 hasConceptScore W2013084549C2776557347 @default.
- W2013084549 hasConceptScore W2013084549C2778337571 @default.
- W2013084549 hasConceptScore W2013084549C2778384902 @default.
- W2013084549 hasConceptScore W2013084549C2778917026 @default.
- W2013084549 hasConceptScore W2013084549C42219234 @default.
- W2013084549 hasConceptScore W2013084549C70289976 @default.
- W2013084549 hasConceptScore W2013084549C71924100 @default.
- W2013084549 hasIssue "4" @default.
- W2013084549 hasLocation W20130845491 @default.
- W2013084549 hasLocation W20130845492 @default.
- W2013084549 hasOpenAccess W2013084549 @default.
- W2013084549 hasPrimaryLocation W20130845491 @default.
- W2013084549 hasRelatedWork W2039745812 @default.
- W2013084549 hasRelatedWork W2089643389 @default.
- W2013084549 hasRelatedWork W2094751618 @default.
- W2013084549 hasRelatedWork W2125676862 @default.
- W2013084549 hasRelatedWork W2315053804 @default.
- W2013084549 hasRelatedWork W2349182024 @default.
- W2013084549 hasRelatedWork W2381827323 @default.
- W2013084549 hasRelatedWork W2907315839 @default.
- W2013084549 hasRelatedWork W562641976 @default.
- W2013084549 hasRelatedWork W66019951 @default.
- W2013084549 hasVolume "156" @default.
- W2013084549 isParatext "false" @default.
- W2013084549 isRetracted "false" @default.
- W2013084549 magId "2013084549" @default.
- W2013084549 workType "article" @default.