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- W2013088105 abstract "PURPOSE: The CentriMag® VAS has been used to support >100 adult cardiogenic shock patients as a bridge to decision for up to 14 days. The purpose of this project is to modify/test the system for its potential in treating pediatric patients for the same indication for use. METHODS: This MagLev System is comprised of a polycarbonate centrifugal pump without mechanical bearings or seals, a motor, drive console and cannulae. The motor levitates the rotor magnetically so that rotation may be achieved without wear to reduce thrombus formation/minimize hemolysis. The system was evaluated in 4 lambs (12–19 kg): 3 acute (≤ 24 hours) and one chronic (5-day) study. Pump hemodynamics, Hct, Hgb, platelet count and PFH values were monitored at baseline, every 4 hours for the 1st post-op day and daily thereafter. Necropsy and pump retrieval examination were performed at study termination. RESULTS: Flows averaged 0.99+/-0.11 lpm (range 0.75 to 1.20 lpm). PFH averaged ∼10 mg %. Platelet count, total protein and fibrinogen levels remained stable. No end organ dysfunction was observed. No organ infarcts or thromboembolism were seen. CONCLUSIONS: This initial trial supports our hypothesis that the CentriMag® VAS can provide cardiac assistance for pediatric patients. We documented satisfactory pump performance in small animals for the intended duration of use. Hemolysis generation (PFH) was low, changes in hematological indices were unremarkable, and organ function was preserved. (Supported by R43 HL07 1376 from NHLBI, NIH).Figure" @default.
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- W2013088105 date "2005-03-01" @default.
- W2013088105 modified "2023-09-24" @default.
- W2013088105 title "EVALUATION OF THE LEVITRONIX?? CENTRIMAG?? VAS FOR PEDIATRIC USE" @default.
- W2013088105 doi "https://doi.org/10.1097/00002480-200503000-00174" @default.
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