Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013091034> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2013091034 endingPage "427" @default.
- W2013091034 startingPage "421" @default.
- W2013091034 abstract "Twelve pigeons were successfully (ED50 = 2.4 mg/kg p.o.) trained to discriminate the 5-HT(1A/B) receptor agonist eltoprazine (5.0 mg/kg p.o.) from its vehicle in a fixed-ratio (FR)30 two-key operant drug discrimination procedure. Tests for generalization and antagonism showed that 5-HT1A receptor agonists, such as 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) (66.7%), flesinoxan (72.7%), buspirone (58.3%), and ipsapirone (36.4%) only partially substituted for the eltoprazine cue. Compounds with mixed agonistic action at 5-HT1 receptors, completely (> or = 80%) [(eltoprazine; TFMPP (1-(3-trifluoromethylphenyl) piperazine (ED50 = 7.68 mg/kg) and RU 24969 (5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl-1H-indole) (ED50 = 15.8 mg/kg)] substituted for eltoprazine; whereas m-CPP (1-(3-chlorophenyl)piperazine) did not. The selective 5-HT reuptake inhibitor fluvoxamine partially (44%) substituted for the eltoprazine cue. The 5-HT1A receptor antagonist NAN-190 (1-(2-methoxyphenyl)-4-[4-(2-phtalimido)butyl]piperazine) fully blocked the eltoprazine cue. Both (+/-)-pindolol and (+/-)-propranolol showed partial antagonism of the eltoprazine cue (66.7 and 50.0%, respectively). (+/-)-Pindolol also showed partial substitution (50%) for the eltoprazine cue, but NAN-190 and (+/-)propranolol did not. It is concluded that the discriminatory stimulus properties of eltoprazine in the pigeon are mediated by 5-HT1A and 5-HT1B receptors." @default.
- W2013091034 created "2016-06-24" @default.
- W2013091034 creator A5016170581 @default.
- W2013091034 creator A5019986826 @default.
- W2013091034 creator A5020792721 @default.
- W2013091034 creator A5026623910 @default.
- W2013091034 creator A5043621248 @default.
- W2013091034 creator A5054951136 @default.
- W2013091034 creator A5065780840 @default.
- W2013091034 date "1999-10-01" @default.
- W2013091034 modified "2023-09-27" @default.
- W2013091034 title "Discriminative Stimulus Properties of Eltoprazine in the Pigeon" @default.
- W2013091034 cites W1967855090 @default.
- W2013091034 cites W1994191486 @default.
- W2013091034 cites W2001850627 @default.
- W2013091034 cites W2006489254 @default.
- W2013091034 cites W2012087738 @default.
- W2013091034 cites W2014471051 @default.
- W2013091034 cites W2049512449 @default.
- W2013091034 cites W2049580109 @default.
- W2013091034 cites W2056761692 @default.
- W2013091034 cites W2067847029 @default.
- W2013091034 cites W2076496724 @default.
- W2013091034 cites W2087396777 @default.
- W2013091034 cites W2102154317 @default.
- W2013091034 cites W2125921772 @default.
- W2013091034 cites W2140691682 @default.
- W2013091034 cites W2264321533 @default.
- W2013091034 cites W2312806913 @default.
- W2013091034 cites W2334084158 @default.
- W2013091034 doi "https://doi.org/10.1016/s0091-3057(99)00073-8" @default.
- W2013091034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10515324" @default.
- W2013091034 hasPublicationYear "1999" @default.
- W2013091034 type Work @default.
- W2013091034 sameAs 2013091034 @default.
- W2013091034 citedByCount "4" @default.
- W2013091034 crossrefType "journal-article" @default.
- W2013091034 hasAuthorship W2013091034A5016170581 @default.
- W2013091034 hasAuthorship W2013091034A5019986826 @default.
- W2013091034 hasAuthorship W2013091034A5020792721 @default.
- W2013091034 hasAuthorship W2013091034A5026623910 @default.
- W2013091034 hasAuthorship W2013091034A5043621248 @default.
- W2013091034 hasAuthorship W2013091034A5054951136 @default.
- W2013091034 hasAuthorship W2013091034A5065780840 @default.
- W2013091034 hasConcept C170493617 @default.
- W2013091034 hasConcept C185592680 @default.
- W2013091034 hasConcept C2775864247 @default.
- W2013091034 hasConcept C2777287423 @default.
- W2013091034 hasConcept C2778362415 @default.
- W2013091034 hasConcept C2778499207 @default.
- W2013091034 hasConcept C2778938600 @default.
- W2013091034 hasConcept C2780831388 @default.
- W2013091034 hasConcept C55493867 @default.
- W2013091034 hasConcept C71924100 @default.
- W2013091034 hasConcept C98274493 @default.
- W2013091034 hasConceptScore W2013091034C170493617 @default.
- W2013091034 hasConceptScore W2013091034C185592680 @default.
- W2013091034 hasConceptScore W2013091034C2775864247 @default.
- W2013091034 hasConceptScore W2013091034C2777287423 @default.
- W2013091034 hasConceptScore W2013091034C2778362415 @default.
- W2013091034 hasConceptScore W2013091034C2778499207 @default.
- W2013091034 hasConceptScore W2013091034C2778938600 @default.
- W2013091034 hasConceptScore W2013091034C2780831388 @default.
- W2013091034 hasConceptScore W2013091034C55493867 @default.
- W2013091034 hasConceptScore W2013091034C71924100 @default.
- W2013091034 hasConceptScore W2013091034C98274493 @default.
- W2013091034 hasIssue "2" @default.
- W2013091034 hasLocation W20130910341 @default.
- W2013091034 hasLocation W20130910342 @default.
- W2013091034 hasOpenAccess W2013091034 @default.
- W2013091034 hasPrimaryLocation W20130910341 @default.
- W2013091034 hasRelatedWork W1968195171 @default.
- W2013091034 hasRelatedWork W1980396625 @default.
- W2013091034 hasRelatedWork W1981898266 @default.
- W2013091034 hasRelatedWork W1988938918 @default.
- W2013091034 hasRelatedWork W1999450232 @default.
- W2013091034 hasRelatedWork W2068156360 @default.
- W2013091034 hasRelatedWork W2076686084 @default.
- W2013091034 hasRelatedWork W2095312450 @default.
- W2013091034 hasRelatedWork W2137950391 @default.
- W2013091034 hasRelatedWork W84973167 @default.
- W2013091034 hasVolume "64" @default.
- W2013091034 isParatext "false" @default.
- W2013091034 isRetracted "false" @default.
- W2013091034 magId "2013091034" @default.
- W2013091034 workType "article" @default.