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- W2013091488 abstract "Genetic recombination in Escherichia coli is stimulated at DNA sequences known as Chi sites, 5'-GCT-GGTGG-3'. We describe the in vitro formation of homologously paired joint molecules that is dependent upon this recombination hotspot. Chi-dependent joint molecule formation requires RecA, RecBCD, and SSB proteins and a Chi site in the donor linear dsDNA. The donor dsDNA is unwound by RecBCD enzyme, and the invasive strand is generated by nicking at Chi. This Chi-dependent invading strand must contain homology to the recipient supercoiled DNA substrate at its newly formed 3' end for efficient joint molecule formation. Action at Chi generates invasive ssDNA from the 5' but not the 3' side of Chi, suggesting that the nuclease activity of RecBCD enzyme is attenuated upon encountering a Chi site. These results support the view that RecBCD enzyme action can precede RecA protein action and reconcile the seemingly opposing degradative and recombination functions of RecBCD enzyme." @default.
- W2013091488 created "2016-06-24" @default.
- W2013091488 creator A5032365839 @default.
- W2013091488 creator A5034221761 @default.
- W2013091488 date "1991-07-01" @default.
- W2013091488 modified "2023-09-30" @default.
- W2013091488 title "Homologous pairing in vitro stimulated by the recombination Hotspot, Chi" @default.
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- W2013091488 doi "https://doi.org/10.1016/0092-8674(91)90625-9" @default.
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