FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013092859> ?p ?o ?g. }

• W2013092859 endingPage "133" @default.
• W2013092859 startingPage "119" @default.
• W2013092859 abstract "Antibody producing B‐cells are an essential component of the immune system. In contrast to human and mice where B‐cells develop in the bone marrow, chicken B‐cells develop in defined stages in the bursa of Fabricius, a gut associated lymphoid tissue. In order to gain a better understanding of critical biological processes like immigration of B‐cell precursors into the bursa anlage, their differentiation and final emigration from the bursa we analyzed the proteome dynamics of this organ during embryonic and posthatch development. Samples were taken from four representative developmental stages (embryonic day (ED) 10, ED18, day 2, and day 28) and compared in an extensive 2D DIGE approach comprising six biological replicates per time point. Cluster analysis and PCA demonstrated high reliability and reproducibility of the obtained data set and revealed distinctive proteome profiles for the selected time points, which precisely reflect the differentiation processes. One hundred fifty three protein spots with significantly different intensities were identified by MS. We detected alterations in the abundance of several proteins assigned to retinoic acid metabolism (e.g. retinal‐binding protein 5) and the actin‐cytoskeleton (e.g. vinculin and gelsolin). By immunohistochemistry, desmin was identified as stromal cell protein associated with the maturation of B‐cell follicles. Strongest protein expression difference (10.8‐fold) was observed for chloride intracellular channel 2. This protein was thus far not associated with B‐cell biology but our data suggest an important function in bursa B‐cell development." @default.
• W2013092859 created "2016-06-24" @default.
• W2013092859 creator A5002929265 @default.
• W2013092859 creator A5006590303 @default.
• W2013092859 creator A5010867829 @default.
• W2013092859 creator A5044175561 @default.
• W2013092859 creator A5048122943 @default.
• W2013092859 creator A5056963214 @default.
• W2013092859 date "2012-12-05" @default.
• W2013092859 modified "2023-10-18" @default.
• W2013092859 title "2D DIGE analysis of the bursa of Fabricius reveals characteristic proteome profiles for different stages of chicken B-cell development" @default.
• W2013092859 cites W1557239654 @default.
• W2013092859 cites W1583997555 @default.
• W2013092859 cites W1678024584 @default.
• W2013092859 cites W1975580833 @default.
• W2013092859 cites W1976678782 @default.
• W2013092859 cites W1979299513 @default.
• W2013092859 cites W1985586934 @default.
• W2013092859 cites W1985596675 @default.
• W2013092859 cites W1986745887 @default.
• W2013092859 cites W1997058261 @default.
• W2013092859 cites W1999516176 @default.
• W2013092859 cites W2002505824 @default.
• W2013092859 cites W2013306932 @default.
• W2013092859 cites W2013688915 @default.
• W2013092859 cites W2014995247 @default.
• W2013092859 cites W2017438217 @default.
• W2013092859 cites W2024524102 @default.
• W2013092859 cites W202503473 @default.
• W2013092859 cites W2038963156 @default.
• W2013092859 cites W2044876426 @default.
• W2013092859 cites W2047979775 @default.
• W2013092859 cites W2050265473 @default.
• W2013092859 cites W2050417626 @default.
• W2013092859 cites W2051113765 @default.
• W2013092859 cites W2053742656 @default.
• W2013092859 cites W2057902325 @default.
• W2013092859 cites W2061622137 @default.
• W2013092859 cites W2064646902 @default.
• W2013092859 cites W2065381832 @default.
• W2013092859 cites W2066640119 @default.
• W2013092859 cites W2069555620 @default.
• W2013092859 cites W2072173537 @default.
• W2013092859 cites W2072325753 @default.
• W2013092859 cites W2077157308 @default.
• W2013092859 cites W2079752228 @default.
• W2013092859 cites W2080685125 @default.
• W2013092859 cites W2089881524 @default.
• W2013092859 cites W2092185055 @default.
• W2013092859 cites W2092319413 @default.
• W2013092859 cites W2093451145 @default.
• W2013092859 cites W2094480324 @default.
• W2013092859 cites W2095384546 @default.
• W2013092859 cites W2099761180 @default.
• W2013092859 cites W2102905141 @default.
• W2013092859 cites W2106374411 @default.
• W2013092859 cites W2113313059 @default.
• W2013092859 cites W2133537577 @default.
• W2013092859 cites W2135725575 @default.
• W2013092859 cites W2145407859 @default.
• W2013092859 cites W2157519381 @default.
• W2013092859 cites W2158390644 @default.
• W2013092859 cites W2159758114 @default.
• W2013092859 cites W2162087337 @default.
• W2013092859 cites W2166638711 @default.
• W2013092859 cites W2168572905 @default.
• W2013092859 cites W23476436 @default.
• W2013092859 doi "https://doi.org/10.1002/pmic.201200177" @default.
• W2013092859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23135993" @default.
• W2013092859 hasPublicationYear "2012" @default.
• W2013092859 type Work @default.
• W2013092859 sameAs 2013092859 @default.
• W2013092859 citedByCount "26" @default.
• W2013092859 countsByYear W20130928592013 @default.
• W2013092859 countsByYear W20130928592014 @default.
• W2013092859 countsByYear W20130928592015 @default.
• W2013092859 countsByYear W20130928592016 @default.
• W2013092859 countsByYear W20130928592017 @default.
• W2013092859 countsByYear W20130928592018 @default.
• W2013092859 countsByYear W20130928592019 @default.
• W2013092859 countsByYear W20130928592020 @default.
• W2013092859 countsByYear W20130928592021 @default.
• W2013092859 countsByYear W20130928592022 @default.
• W2013092859 crossrefType "journal-article" @default.
• W2013092859 hasAuthorship W2013092859A5002929265 @default.
• W2013092859 hasAuthorship W2013092859A5006590303 @default.
• W2013092859 hasAuthorship W2013092859A5010867829 @default.
• W2013092859 hasAuthorship W2013092859A5044175561 @default.
• W2013092859 hasAuthorship W2013092859A5048122943 @default.
• W2013092859 hasAuthorship W2013092859A5056963214 @default.
• W2013092859 hasConcept C104317684 @default.
• W2013092859 hasConcept C104397665 @default.
• W2013092859 hasConcept C147447768 @default.
• W2013092859 hasConcept C148738053 @default.
• W2013092859 hasConcept C153911025 @default.
• W2013092859 hasConcept C159654299 @default.
• W2013092859 hasConcept C16930146 @default.
• W2013092859 hasConcept C178596410 @default.

• next