FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013094189> ?p ?o ?g. }

• W2013094189 endingPage "206" @default.
• W2013094189 startingPage "200" @default.
• W2013094189 abstract "Cerebral ischemia is caused by reduced blood supply at the microcirculatory level. In the microvessels, the main elements of the reperfusion injury following brain ischemia are the transformation of endothelial cell-surface from anticoagulant to procoagulant property, leukocyte adhesion, sludge or clot formation. There is a paucity of information on how hemostatic factors, cytokines, lipoprotein(a) (Lp(a)) and endothelin-1 (ET-1), being responsible for ischemic/reperfusion injury, interact with human brain microvessel endothelium (HBEC). There are no data furthermore about the expression of complement proteins of HBEC influenced by cytokines or fibrinolytic factors. Previously we established optimal conditions for culturing HBEC. Cell contraction induced by thrombin, plasmin, miniplasmin was recorded. The reassembly of F-actin was observed after thrombin treatment. ICAM-1 upregulation was measured following TNF-α, IL-1-α and thrombin incubation. Plasmin and miniplasmin downregulated the ICAM-1 in our cell culture system. Lp(a) modulated the thromboresistant cell-surface by reduction of t-PA and u-PA, but PAM remained unchanged. Lp(a) modulated the ET-1 production by early increasing and late decreasing, in a bimodal manner. The increased secretion of ET-1 by cytokines (TNF-α, IL-1-α) was reduced in the presence of Lp(a). Gradual increase of complement proteins (factor H, factor B, C4) was induced by cytokines. Plasmin and miniplasmin augmented a rapid increase of C4. Some factors of complex relationship between regulators and modulators of endothelial adhesion molecules have been demonstrated in a human cell culture system prepared from brain microvessel endothelium. A unified concept of sequential events of ischemia/reperfusion in the brain has not yet developed." @default.
• W2013094189 created "2016-06-24" @default.
• W2013094189 creator A5015316522 @default.
• W2013094189 creator A5019832300 @default.
• W2013094189 creator A5035087735 @default.
• W2013094189 creator A5042841763 @default.
• W2013094189 creator A5049171111 @default.
• W2013094189 creator A5056780617 @default.
• W2013094189 creator A5063209296 @default.
• W2013094189 creator A5081492922 @default.
• W2013094189 date "1996-01-01" @default.
• W2013094189 modified "2023-10-12" @default.
• W2013094189 title "Human Brain Microvessel Endothelial Cell Culture as a Model System to Study Vascular Factors of Ischemic Brain." @default.
• W2013094189 cites W1505588706 @default.
• W2013094189 cites W1525482898 @default.
• W2013094189 cites W1594394126 @default.
• W2013094189 cites W1966353295 @default.
• W2013094189 cites W1989077639 @default.
• W2013094189 cites W2003843444 @default.
• W2013094189 cites W2005432768 @default.
• W2013094189 cites W2013507425 @default.
• W2013094189 cites W2015689800 @default.
• W2013094189 cites W2036170644 @default.
• W2013094189 cites W2052837799 @default.
• W2013094189 cites W2054566913 @default.
• W2013094189 cites W2056096799 @default.
• W2013094189 cites W2065238062 @default.
• W2013094189 cites W2067436359 @default.
• W2013094189 cites W2092084919 @default.
• W2013094189 cites W2098271606 @default.
• W2013094189 cites W2100124039 @default.
• W2013094189 cites W2106561229 @default.
• W2013094189 cites W2112505121 @default.
• W2013094189 cites W2136496671 @default.
• W2013094189 cites W2399464812 @default.
• W2013094189 cites W2404783726 @default.
• W2013094189 cites W2413279894 @default.
• W2013094189 cites W2413286740 @default.
• W2013094189 cites W2417519160 @default.
• W2013094189 cites W2417749014 @default.
• W2013094189 cites W26959667 @default.
• W2013094189 cites W41215289 @default.
• W2013094189 cites W147845702 @default.
• W2013094189 doi "https://doi.org/10.2302/kjm.45.200" @default.
• W2013094189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8897762" @default.
• W2013094189 hasPublicationYear "1996" @default.
• W2013094189 type Work @default.
• W2013094189 sameAs 2013094189 @default.
• W2013094189 citedByCount "12" @default.
• W2013094189 countsByYear W20130941892014 @default.
• W2013094189 countsByYear W20130941892017 @default.
• W2013094189 countsByYear W20130941892018 @default.
• W2013094189 crossrefType "journal-article" @default.
• W2013094189 hasAuthorship W2013094189A5015316522 @default.
• W2013094189 hasAuthorship W2013094189A5019832300 @default.
• W2013094189 hasAuthorship W2013094189A5035087735 @default.
• W2013094189 hasAuthorship W2013094189A5042841763 @default.
• W2013094189 hasAuthorship W2013094189A5049171111 @default.
• W2013094189 hasAuthorship W2013094189A5056780617 @default.
• W2013094189 hasAuthorship W2013094189A5063209296 @default.
• W2013094189 hasAuthorship W2013094189A5081492922 @default.
• W2013094189 hasBestOaLocation W20130941891 @default.
• W2013094189 hasConcept C104317684 @default.
• W2013094189 hasConcept C123012128 @default.
• W2013094189 hasConcept C127561419 @default.
• W2013094189 hasConcept C134018914 @default.
• W2013094189 hasConcept C16224149 @default.
• W2013094189 hasConcept C164027704 @default.
• W2013094189 hasConcept C181199279 @default.
• W2013094189 hasConcept C185592680 @default.
• W2013094189 hasConcept C202751555 @default.
• W2013094189 hasConcept C203014093 @default.
• W2013094189 hasConcept C204232928 @default.
• W2013094189 hasConcept C2776436680 @default.
• W2013094189 hasConcept C2776914184 @default.
• W2013094189 hasConcept C2776992346 @default.
• W2013094189 hasConcept C2777292125 @default.
• W2013094189 hasConcept C2781071845 @default.
• W2013094189 hasConcept C55493867 @default.
• W2013094189 hasConcept C86803240 @default.
• W2013094189 hasConcept C89560881 @default.
• W2013094189 hasConcept C95444343 @default.
• W2013094189 hasConceptScore W2013094189C104317684 @default.
• W2013094189 hasConceptScore W2013094189C123012128 @default.
• W2013094189 hasConceptScore W2013094189C127561419 @default.
• W2013094189 hasConceptScore W2013094189C134018914 @default.
• W2013094189 hasConceptScore W2013094189C16224149 @default.
• W2013094189 hasConceptScore W2013094189C164027704 @default.
• W2013094189 hasConceptScore W2013094189C181199279 @default.
• W2013094189 hasConceptScore W2013094189C185592680 @default.
• W2013094189 hasConceptScore W2013094189C202751555 @default.
• W2013094189 hasConceptScore W2013094189C203014093 @default.
• W2013094189 hasConceptScore W2013094189C204232928 @default.
• W2013094189 hasConceptScore W2013094189C2776436680 @default.
• W2013094189 hasConceptScore W2013094189C2776914184 @default.
• W2013094189 hasConceptScore W2013094189C2776992346 @default.
• W2013094189 hasConceptScore W2013094189C2777292125 @default.
• W2013094189 hasConceptScore W2013094189C2781071845 @default.

• next