FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013097789> ?p ?o ?g. }

• W2013097789 endingPage "e40422" @default.
• W2013097789 startingPage "e40422" @default.
• W2013097789 abstract "The propagation of influenza A virus depends on the balance between the activities of hemagglutinin (HA) for binding to host cells and neuraminidase (NA) for releasing from infected cells (HA-NA balance). Since the host cell membrane and the sialic acid receptor are negatively charged, the amino acid substitutions increasing (charge+) and decreasing (charge-) the positive charge of HA subunit 1 (HA1) enhance and reduce, respectively, the binding avidity and affinity. The positive charge of HA1 in human influenza A virus bearing subtype H3N2 (A/H3N2 virus) was observed to have increased during evolution, but the evolutionary mechanism for this observation was unclear because this may disrupt the HA-NA balance. Here we show, from the phylogenetic analysis of HA for human A/H3N2 and A/H1N1 viruses, that the relative frequencies of charge+ and charge- substitutions were elevated on the branches where the number of N-glycosylation sites (NGS) increased and decreased, respectively, compared to those where the number of NGS did not change. On the latter branches, the net-charge of HA1 appeared to have been largely maintained to preserve its structure and function. Since the charge+ and charge- substitutions in HA1 have opposite effects to the gain and loss of NGS on the binding and release of the virus, the net-charge of HA1 may have evolved to compensate for the effect of the gain and loss of NGS, probably through changing the avidity. Apparently, the relative frequency of charge- substitutions in HA1 of A/H3N2 virus was elevated after the introduction of oseltamivir, and that of charge+ substitutions in HA1 of A/H1N1 virus was elevated after the spread of oseltamivir resistance. These observations may also be explained by the compensatory effect of the net-charge in HA1 on the NA activity for keeping the HA-NA balance." @default.
• W2013097789 created "2016-06-24" @default.
• W2013097789 creator A5077045599 @default.
• W2013097789 creator A5089243471 @default.
• W2013097789 date "2012-07-12" @default.
• W2013097789 modified "2023-10-17" @default.
• W2013097789 title "Compensatory Evolution of Net-Charge in Influenza A Virus Hemagglutinin" @default.
• W2013097789 cites W1967722210 @default.
• W2013097789 cites W1968248848 @default.
• W2013097789 cites W1969443738 @default.
• W2013097789 cites W1984412128 @default.
• W2013097789 cites W1984416131 @default.
• W2013097789 cites W1988533731 @default.
• W2013097789 cites W1989567051 @default.
• W2013097789 cites W1989639957 @default.
• W2013097789 cites W1994689173 @default.
• W2013097789 cites W1994961743 @default.
• W2013097789 cites W1996404764 @default.
• W2013097789 cites W2017618875 @default.
• W2013097789 cites W2046094044 @default.
• W2013097789 cites W2053407859 @default.
• W2013097789 cites W2055984914 @default.
• W2013097789 cites W2069322612 @default.
• W2013097789 cites W2070521125 @default.
• W2013097789 cites W2078368610 @default.
• W2013097789 cites W2082928585 @default.
• W2013097789 cites W2083419156 @default.
• W2013097789 cites W2102335249 @default.
• W2013097789 cites W2106180988 @default.
• W2013097789 cites W2107651145 @default.
• W2013097789 cites W2108573701 @default.
• W2013097789 cites W2109874333 @default.
• W2013097789 cites W2110335151 @default.
• W2013097789 cites W2110998010 @default.
• W2013097789 cites W2121687973 @default.
• W2013097789 cites W2126887491 @default.
• W2013097789 cites W2127774996 @default.
• W2013097789 cites W2129587690 @default.
• W2013097789 cites W2132632499 @default.
• W2013097789 cites W2142254134 @default.
• W2013097789 cites W2147202849 @default.
• W2013097789 cites W2148298538 @default.
• W2013097789 cites W2154072371 @default.
• W2013097789 cites W2154767456 @default.
• W2013097789 cites W2156554308 @default.
• W2013097789 cites W2158616404 @default.
• W2013097789 cites W2163892779 @default.
• W2013097789 cites W2170731906 @default.
• W2013097789 cites W2417822211 @default.
• W2013097789 doi "https://doi.org/10.1371/journal.pone.0040422" @default.
• W2013097789 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3395715" @default.
• W2013097789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22808159" @default.
• W2013097789 hasPublicationYear "2012" @default.
• W2013097789 type Work @default.
• W2013097789 sameAs 2013097789 @default.
• W2013097789 citedByCount "37" @default.
• W2013097789 countsByYear W20130977892012 @default.
• W2013097789 countsByYear W20130977892013 @default.
• W2013097789 countsByYear W20130977892014 @default.
• W2013097789 countsByYear W20130977892015 @default.
• W2013097789 countsByYear W20130977892016 @default.
• W2013097789 countsByYear W20130977892017 @default.
• W2013097789 countsByYear W20130977892018 @default.
• W2013097789 countsByYear W20130977892019 @default.
• W2013097789 countsByYear W20130977892020 @default.
• W2013097789 countsByYear W20130977892021 @default.
• W2013097789 countsByYear W20130977892022 @default.
• W2013097789 countsByYear W20130977892023 @default.
• W2013097789 crossrefType "journal-article" @default.
• W2013097789 hasAuthorship W2013097789A5077045599 @default.
• W2013097789 hasAuthorship W2013097789A5089243471 @default.
• W2013097789 hasBestOaLocation W20130977891 @default.
• W2013097789 hasConcept C121332964 @default.
• W2013097789 hasConcept C12554922 @default.
• W2013097789 hasConcept C134164806 @default.
• W2013097789 hasConcept C159047783 @default.
• W2013097789 hasConcept C159654299 @default.
• W2013097789 hasConcept C179223381 @default.
• W2013097789 hasConcept C185592680 @default.
• W2013097789 hasConcept C188082385 @default.
• W2013097789 hasConcept C2522874641 @default.
• W2013097789 hasConcept C2777546802 @default.
• W2013097789 hasConcept C2778692840 @default.
• W2013097789 hasConcept C54355233 @default.
• W2013097789 hasConcept C62520636 @default.
• W2013097789 hasConcept C86803240 @default.
• W2013097789 hasConceptScore W2013097789C121332964 @default.
• W2013097789 hasConceptScore W2013097789C12554922 @default.
• W2013097789 hasConceptScore W2013097789C134164806 @default.
• W2013097789 hasConceptScore W2013097789C159047783 @default.
• W2013097789 hasConceptScore W2013097789C159654299 @default.
• W2013097789 hasConceptScore W2013097789C179223381 @default.
• W2013097789 hasConceptScore W2013097789C185592680 @default.
• W2013097789 hasConceptScore W2013097789C188082385 @default.
• W2013097789 hasConceptScore W2013097789C2522874641 @default.
• W2013097789 hasConceptScore W2013097789C2777546802 @default.
• W2013097789 hasConceptScore W2013097789C2778692840 @default.
• W2013097789 hasConceptScore W2013097789C54355233 @default.

• next