FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013102789> ?p ?o ?g. }

• W2013102789 abstract "Summary 1. Chlorhexidine digluconate has been used as a topical antiseptic in the treatment of acne vulgaris and periodontitis. The acute phase of these diseases involves neutrophilic infiltration. Neutrophil activation and recruitment to inflammatory sites are crucial in both protection against bacterial infection and the induction of hystotoxic damage. Activated neutrophils release several enzymes, including elastase and myeloperoxidase (MPO), which contribute to tissue injury via direct toxic actions, the generation of oxidants and inactivation of protective factors, such as α1‐antitrypsin (α1‐AT). In the present study, we investigated whether chlorhexidine can modulate neutrophil‐mediated histotoxicity. 2. Human primary neutrophils were isolated from healthy donors. Inactivation of α1‐AT by neutrophils or hypochlorous acid (HOCl) was evaluated by spectrophotometry and sodium dodecyl sulphate–polyacrylamide gel electrophoresis analysis of its capacity to complex with porcine pancreatic elastase (PPE). Neutrophil generation of HOCl, superoxide anion and MPO release were assessed spectrophometrically. 3. Chlorhexidine (0, 0.5, 1, 5 and 10 μmol/L) dose‐dependently prevented HOCl‐induced inactivation of α1‐AT and reduced HOCl recovery from phorbol myristate acetate (PMA)‐treated human neutrophils, but did not inhibit superoxide anion and MPO release. Chlorhexidine directly inhibited HOCl recovery from neutrophils and HOCl‐induced inactivation of α1‐AT in a cell‐free assay. Accordingly, chlorhexidine reversed HOCl‐mediated inhibition of α1‐AT capacity to complex with PPE. 4. These data suggest that chlorhexidine prevents neutrophil‐induced α1‐AT inactivation via a direct inhibitory action on HOCl. Although highly speculative, the present study indicates that chlorhexidine may protect inflamed tissues not only through its antimicrobial properties, but also via a direct anti‐inflammatory effect on neutrophil toxic products." @default.
• W2013102789 created "2016-06-24" @default.
• W2013102789 creator A5000488097 @default.
• W2013102789 creator A5024812334 @default.
• W2013102789 creator A5042094771 @default.
• W2013102789 creator A5046354199 @default.
• W2013102789 creator A5055297433 @default.
• W2013102789 creator A5061225153 @default.
• W2013102789 creator A5072146670 @default.
• W2013102789 creator A5085573148 @default.
• W2013102789 date "2009-11-01" @default.
• W2013102789 modified "2023-10-18" @default.
• W2013102789 title "Chlorhexidine prevents hypochlorous acid-induced inactivation of α1-antitrypsin" @default.
• W2013102789 cites W153768368 @default.
• W2013102789 cites W1784724717 @default.
• W2013102789 cites W1964656764 @default.
• W2013102789 cites W1970128167 @default.
• W2013102789 cites W1970755930 @default.
• W2013102789 cites W1979138042 @default.
• W2013102789 cites W1983972705 @default.
• W2013102789 cites W1994285144 @default.
• W2013102789 cites W2005714593 @default.
• W2013102789 cites W2015688293 @default.
• W2013102789 cites W2020784996 @default.
• W2013102789 cites W2026186574 @default.
• W2013102789 cites W2034326874 @default.
• W2013102789 cites W2050263124 @default.
• W2013102789 cites W2053785902 @default.
• W2013102789 cites W2057099776 @default.
• W2013102789 cites W2064290859 @default.
• W2013102789 cites W2078854698 @default.
• W2013102789 cites W2079324144 @default.
• W2013102789 cites W2080274411 @default.
• W2013102789 cites W2081114530 @default.
• W2013102789 cites W2098331318 @default.
• W2013102789 cites W2117966002 @default.
• W2013102789 cites W2128080558 @default.
• W2013102789 cites W2135718925 @default.
• W2013102789 cites W2141532688 @default.
• W2013102789 cites W2144044455 @default.
• W2013102789 cites W2155008443 @default.
• W2013102789 cites W2166262719 @default.
• W2013102789 cites W2328115008 @default.
• W2013102789 cites W2429584649 @default.
• W2013102789 cites W3035322935 @default.
• W2013102789 cites W4247113824 @default.
• W2013102789 cites W4294658238 @default.
• W2013102789 doi "https://doi.org/10.1111/j.1440-1681.2009.05270.x" @default.
• W2013102789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19671069" @default.
• W2013102789 hasPublicationYear "2009" @default.
• W2013102789 type Work @default.
• W2013102789 sameAs 2013102789 @default.
• W2013102789 citedByCount "12" @default.
• W2013102789 countsByYear W20131027892012 @default.
• W2013102789 countsByYear W20131027892013 @default.
• W2013102789 countsByYear W20131027892014 @default.
• W2013102789 countsByYear W20131027892015 @default.
• W2013102789 countsByYear W20131027892017 @default.
• W2013102789 countsByYear W20131027892019 @default.
• W2013102789 countsByYear W20131027892020 @default.
• W2013102789 countsByYear W20131027892023 @default.
• W2013102789 crossrefType "journal-article" @default.
• W2013102789 hasAuthorship W2013102789A5000488097 @default.
• W2013102789 hasAuthorship W2013102789A5024812334 @default.
• W2013102789 hasAuthorship W2013102789A5042094771 @default.
• W2013102789 hasAuthorship W2013102789A5046354199 @default.
• W2013102789 hasAuthorship W2013102789A5055297433 @default.
• W2013102789 hasAuthorship W2013102789A5061225153 @default.
• W2013102789 hasAuthorship W2013102789A5072146670 @default.
• W2013102789 hasAuthorship W2013102789A5085573148 @default.
• W2013102789 hasConcept C160448771 @default.
• W2013102789 hasConcept C181199279 @default.
• W2013102789 hasConcept C185592680 @default.
• W2013102789 hasConcept C199343813 @default.
• W2013102789 hasConcept C203014093 @default.
• W2013102789 hasConcept C203565725 @default.
• W2013102789 hasConcept C2775838275 @default.
• W2013102789 hasConcept C2776317360 @default.
• W2013102789 hasConcept C2776914184 @default.
• W2013102789 hasConcept C2777084678 @default.
• W2013102789 hasConcept C2780795997 @default.
• W2013102789 hasConcept C2780908991 @default.
• W2013102789 hasConcept C2781044401 @default.
• W2013102789 hasConcept C55493867 @default.
• W2013102789 hasConcept C71924100 @default.
• W2013102789 hasConcept C86803240 @default.
• W2013102789 hasConcept C89423630 @default.
• W2013102789 hasConcept C98274493 @default.
• W2013102789 hasConceptScore W2013102789C160448771 @default.
• W2013102789 hasConceptScore W2013102789C181199279 @default.
• W2013102789 hasConceptScore W2013102789C185592680 @default.
• W2013102789 hasConceptScore W2013102789C199343813 @default.
• W2013102789 hasConceptScore W2013102789C203014093 @default.
• W2013102789 hasConceptScore W2013102789C203565725 @default.
• W2013102789 hasConceptScore W2013102789C2775838275 @default.
• W2013102789 hasConceptScore W2013102789C2776317360 @default.
• W2013102789 hasConceptScore W2013102789C2776914184 @default.
• W2013102789 hasConceptScore W2013102789C2777084678 @default.
• W2013102789 hasConceptScore W2013102789C2780795997 @default.
• W2013102789 hasConceptScore W2013102789C2780908991 @default.

• next