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- W2013103687 abstract "It is acknowledged that T cell interactions with mature dendritic cells (DC) lead to immunity, whereas interactions with immature DC lead to tolerance induction. Using a transgenic murine system, we have examined how DC expressing self-peptides control naive, self-reactive CD8<sup>+</sup> T cell responses in vitro and in vivo. We have shown, for the first time, that immature DC can also stimulate productive activation of naive self-specific CD8<sup>+</sup> T cells, which results in extensive proliferation, the expression of a highly activated cell surface phenotype, and differentiation into autoimmune CTL. Conversely, mature DC can induce abortive activation of naive CD8<sup>+</sup> T cells, which is characterized by low-level proliferation, the expression of a partially activated cell surface phenotype which does not result in autoimmune CTL. Critically, both CD8<sup>+</sup> T cell responses are determined by a combination of signals mediated by the DC, and that altering any one of these signals dramatically shifts the balance between autoimmunity and self-tolerance induction. We hypothesize that DC maintain the steady state of self-tolerance among self-specific CD8<sup>+</sup> T cells in an active and dynamic manner, licensing productive immune responses against self-tissues only when required." @default.
- W2013103687 created "2016-06-24" @default.
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- W2013103687 date "1992-11-01" @default.
- W2013103687 modified "2023-09-25" @default.
- W2013103687 title "Cigarette smoking and small irregular opacities." @default.
- W2013103687 doi "https://doi.org/10.1136/oem.49.11.815" @default.
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