Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013111875> ?p ?o ?g. }
- W2013111875 abstract "Clearance of partially ordered oligomers and monomers deposited on cell membrane surfaces is believed to be an effective route to alleviate many potential protein conformational diseases (PCDs). With large-scale all-atom molecular dynamics simulations, here we show that graphene nanosheets can easily and quickly win a competitive adsorption of human islet amyloid polypeptides (hIAPP22-28) NFGAILS and associated fibrils against cell membrane, due to graphene's unique two-dimensional, highly hydrophobic surface with its all-sp(2) hybrid structure. A nanoscale dewetting transition was observed at the interfacial region between the fibril (originally deposited on the membrane) and the graphene nanosheet, which significantly assisted the adsorption of fibrils onto graphene from the membrane. The π-π stacking interaction between Phe23 and graphene played a crucial role, providing the driving force for the adsorption at the graphene surface. This study renders new insight towards the importance of water during the interactions between amyloid peptides, the phospholipidic membrane, and graphene, which might shed some light on future developments of graphene-based nanomedicine for preventing/curing PCDs like type II diabetes mellitus." @default.
- W2013111875 created "2016-06-24" @default.
- W2013111875 creator A5007431422 @default.
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- W2013111875 creator A5078014032 @default.
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- W2013111875 date "2014-11-10" @default.
- W2013111875 modified "2023-10-17" @default.
- W2013111875 title "Dewetting transition assisted clearance of (NFGAILS) amyloid fibrils from cell membranes by graphene" @default.
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- W2013111875 doi "https://doi.org/10.1063/1.4901113" @default.
- W2013111875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25494791" @default.
- W2013111875 hasPublicationYear "2014" @default.
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