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• W2013114520 abstract "Intracellular phospholipase A2 (PLA2) is responsible for releasing arachidonic acid from cellular phospholipids, and is thought to be the first step in eicosanoid biosynthesis. Intracellular PLA2s have been characterized in fat body and hemocytes from tobacco hornworms, Manduca sexta. Here we show that bacterial challenge stimulated increased PLA2 activity in isolated hemocyte preparations, relative to control hemocyte preparations that were challenged with water. The increased activity was detected as early as 15 s post-challenge and lasted for at least 1 h. The increased activity depended on a minimum bacterial challenge dose, and was inhibited in reactions conducted in the presence of oleyoxyethylphosphorylcholine, a site-specific PLA2 inhibitor. In independent experiments with serum prepared from whole hemolymph, we found no PLA2 activity was secreted into serum during the first 24 h following bacterial infection. We infer that a hemocytic intracellular PLA2 activity is increased immediately an infection is detected. The significance of this enzyme lies in its role in launching the biosynthesis of eicosanoids, which mediate cellular immune reactions to bacterial infection. Arch. Insect Biochem. Physiol. 52:1–6, 2003. © 2003 Wiley-Liss, Inc." @default.
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• W2013114520 date "2002-12-17" @default.
• W2013114520 modified "2023-10-11" @default.
• W2013114520 title "Eicosanoids in insect immunity: Bacterial infection stimulates hemocytic phospholipase A₂activity in tobacco hornworms" @default.
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• W2013114520 doi "https://doi.org/10.1002/arch.10056" @default.
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