Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013114534> ?p ?o ?g. }
- W2013114534 abstract "DURING PREGNANCY, THE MATERNAL IMMUNE SYSTEM FACES A DOUBLE DILEMMA: tolerate the growing semi-allogeneic fetus and at the same time protect the mother and the progeny against pathogens. This requires a fine and extremely regulated equilibrium between immune activation and tolerance. As professional antigen presenting cells, B cells and in particular B-1a B cells, can activate or tolerize T cells and thus participate in the generation or regulation of the immune response. B-1a B cells were involved in the humoral immune response leading to pre-eclampsia, one of the main medical complications during pregnancy. Here we demonstrated that B-1a B cells are additionally involved in cellular immune mechanisms associated with pregnancy complications. Using a mouse model of pregnancy disturbances, we showed that B-1a B cells from animals suffering pregnancy disturbances but not from those developing normal pregnancies induce the differentiation of naïve T cells into Th17 and Th1 cells. This differential role of B-1a B cells during pregnancy seems to be associated with the co-stimulatory molecule CD86 as normal pregnant mice showed lower percentages of CD86 expressing B-1a B cells as compared to pregnant mice developing pregnancy disturbances or to non-pregnant animals. Our data bring to light a new and not explored role of B-1a B cells in the context of pregnancy." @default.
- W2013114534 created "2016-06-24" @default.
- W2013114534 creator A5027393286 @default.
- W2013114534 creator A5039495379 @default.
- W2013114534 creator A5057696929 @default.
- W2013114534 creator A5064847205 @default.
- W2013114534 creator A5067315208 @default.
- W2013114534 creator A5085366797 @default.
- W2013114534 date "2014-01-01" @default.
- W2013114534 modified "2023-10-12" @default.
- W2013114534 title "B-1a B Cells Regulate T Cell Differentiation Associated with Pregnancy Disturbances" @default.
- W2013114534 cites W1553704526 @default.
- W2013114534 cites W1816895212 @default.
- W2013114534 cites W1903362351 @default.
- W2013114534 cites W1939125543 @default.
- W2013114534 cites W1965418852 @default.
- W2013114534 cites W1981141937 @default.
- W2013114534 cites W1982516167 @default.
- W2013114534 cites W1982529683 @default.
- W2013114534 cites W1988706629 @default.
- W2013114534 cites W1993506318 @default.
- W2013114534 cites W1998358627 @default.
- W2013114534 cites W2002811695 @default.
- W2013114534 cites W2004647500 @default.
- W2013114534 cites W2005582607 @default.
- W2013114534 cites W2008559248 @default.
- W2013114534 cites W2015945927 @default.
- W2013114534 cites W2023491212 @default.
- W2013114534 cites W2035291056 @default.
- W2013114534 cites W2038244488 @default.
- W2013114534 cites W2050037736 @default.
- W2013114534 cites W2051203706 @default.
- W2013114534 cites W2070758022 @default.
- W2013114534 cites W2071019594 @default.
- W2013114534 cites W2099295104 @default.
- W2013114534 cites W2113465151 @default.
- W2013114534 cites W2125314742 @default.
- W2013114534 cites W2127739019 @default.
- W2013114534 cites W2148974827 @default.
- W2013114534 cites W2152014155 @default.
- W2013114534 cites W2159959377 @default.
- W2013114534 cites W286799728 @default.
- W2013114534 doi "https://doi.org/10.3389/fimmu.2014.00006" @default.
- W2013114534 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3896948" @default.
- W2013114534 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24478775" @default.
- W2013114534 hasPublicationYear "2014" @default.
- W2013114534 type Work @default.
- W2013114534 sameAs 2013114534 @default.
- W2013114534 citedByCount "29" @default.
- W2013114534 countsByYear W20131145342014 @default.
- W2013114534 countsByYear W20131145342015 @default.
- W2013114534 countsByYear W20131145342016 @default.
- W2013114534 countsByYear W20131145342017 @default.
- W2013114534 countsByYear W20131145342018 @default.
- W2013114534 countsByYear W20131145342019 @default.
- W2013114534 countsByYear W20131145342020 @default.
- W2013114534 countsByYear W20131145342021 @default.
- W2013114534 countsByYear W20131145342022 @default.
- W2013114534 crossrefType "journal-article" @default.
- W2013114534 hasAuthorship W2013114534A5027393286 @default.
- W2013114534 hasAuthorship W2013114534A5039495379 @default.
- W2013114534 hasAuthorship W2013114534A5057696929 @default.
- W2013114534 hasAuthorship W2013114534A5064847205 @default.
- W2013114534 hasAuthorship W2013114534A5067315208 @default.
- W2013114534 hasAuthorship W2013114534A5085366797 @default.
- W2013114534 hasBestOaLocation W20131145341 @default.
- W2013114534 hasConcept C145558887 @default.
- W2013114534 hasConcept C147483822 @default.
- W2013114534 hasConcept C151730666 @default.
- W2013114534 hasConcept C159654299 @default.
- W2013114534 hasConcept C162834538 @default.
- W2013114534 hasConcept C172680121 @default.
- W2013114534 hasConcept C203014093 @default.
- W2013114534 hasConcept C2776090121 @default.
- W2013114534 hasConcept C2777702733 @default.
- W2013114534 hasConcept C2778453870 @default.
- W2013114534 hasConcept C2779234561 @default.
- W2013114534 hasConcept C2779343474 @default.
- W2013114534 hasConcept C2781101188 @default.
- W2013114534 hasConcept C2781438807 @default.
- W2013114534 hasConcept C54355233 @default.
- W2013114534 hasConcept C67662055 @default.
- W2013114534 hasConcept C71924100 @default.
- W2013114534 hasConcept C86803240 @default.
- W2013114534 hasConcept C8891405 @default.
- W2013114534 hasConceptScore W2013114534C145558887 @default.
- W2013114534 hasConceptScore W2013114534C147483822 @default.
- W2013114534 hasConceptScore W2013114534C151730666 @default.
- W2013114534 hasConceptScore W2013114534C159654299 @default.
- W2013114534 hasConceptScore W2013114534C162834538 @default.
- W2013114534 hasConceptScore W2013114534C172680121 @default.
- W2013114534 hasConceptScore W2013114534C203014093 @default.
- W2013114534 hasConceptScore W2013114534C2776090121 @default.
- W2013114534 hasConceptScore W2013114534C2777702733 @default.
- W2013114534 hasConceptScore W2013114534C2778453870 @default.
- W2013114534 hasConceptScore W2013114534C2779234561 @default.
- W2013114534 hasConceptScore W2013114534C2779343474 @default.
- W2013114534 hasConceptScore W2013114534C2781101188 @default.
- W2013114534 hasConceptScore W2013114534C2781438807 @default.
- W2013114534 hasConceptScore W2013114534C54355233 @default.