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• W2013115949 abstract "4-[6-(2-Tertiaryaminoethyl)naphthalen-2-yl]benzonitriles are conformationally constrained histamine H3 receptor antagonists with high potency and selectivity. The analogs were designed around a naphthalene core, with the goal of enhancing lipophilicity and CNS penetration, as compared to a previously reported benzofuran series. The SAR of the tertiary amine moiety is similar to that reported for the benzofuran series, with analogs bearing a 2-methylpyrrolidine substituent possessing the greatest rat and human H3 receptor binding affinities." @default.
• W2013115949 created "2016-06-24" @default.
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• W2013115949 date "2007-03-01" @default.
• W2013115949 modified "2023-10-17" @default.
• W2013115949 title "4-[6-(2-Aminoethyl)naphthalen-2-yl]benzonitriles are potent histamine H3 receptor antagonists with high CNS penetration" @default.
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• W2013115949 doi "https://doi.org/10.1016/j.bmcl.2006.11.073" @default.
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