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- W2013115986 abstract "Small and sustained depolarization induces window current (IWC) through L-type Ca2+ channel that supplies Ca2+ for arterial contraction. Existence of IWC is expected by voltage dependence of steady-state activation and inactivation. However, IWC of arterial smooth muscle has little been characterized by actual current recording. Dehydroepiandrosterone (DHEA) and DHEA-sulphate (DHEA-S) are most abundant adrenal steroid hormones and epiandrosterone (EPI) is a metabolite of DHEA. We recorded ICa,L and IWC with 10 mM Ba2+ as the charge carrier, performed noise analysis and examined effects of the steroids on IWC and its unitary current in bovine coronary artery smooth muscle cells. EPI and DHEA, but not DHEA-S, slightly inhibited ICa,L elicited by depolarization from large negative holding potentials. EPI and DHEA but not DHEA-S shifted steady-state inactivation curve slightly to a negative direction and strongly reduced residual availability at depolarized potentials. IWC elicited by staircase depolarizarion consisted of stair-duration of 20 s appeared at -40 mV and increased up to -10 mV. It decreased with further increase of depolarization. Maximal IWC was 23±2% (n=12) of maximal ICa,L. IWC was associated with marked current noise. IWC and the noise were strongly inhibited by EPI and DHEA, not affected by DHEA-S, and increased by Bay K 8644. Unitary current (iCa,L) and NPo were obtained from mean and variance of IWC. Uunitary conductance (γ) from iCa,L was 17.2 pS. EPI and DHEA decreased NPo and Bay K increased it both without affecting γ. In conclusion, EPI and DHEA inhibit L-type Ca2+ channel window current by accelerating inactivation and thus decreasing the number of opened channels." @default.
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- W2013115986 date "2009-02-01" @default.
- W2013115986 modified "2023-09-28" @default.
- W2013115986 title "Inhibition of L-type Ca2+ Channel Window Current By Steroid Hormones in Coronary Artery Smooth Muscle Cells" @default.
- W2013115986 doi "https://doi.org/10.1016/j.bpj.2008.12.872" @default.
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