FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013116334> ?p ?o ?g. }

• W2013116334 endingPage "456" @default.
• W2013116334 startingPage "448" @default.
• W2013116334 abstract "The collection of epitopes present within the variable regions of the tumor-specific clonal immunoglobulin expressed by B cell lymphomas (idiotype, Id) can serve as a target for active immunotherapy. Traditionally, tumor-derived Id protein is chemically conjugated to the immunogenic foreign carrier protein keyhole limpet hemocyanin (KLH) using glutaraldehyde to serve as a therapeutic vaccine. While this approach offered promising results for some patients treated in early clinical trials, glutaraldehyde Id-KLH vaccines have failed to induce immune and clinical responses in many vaccinated subjects. We recently described an alternative conjugation method employing maleimide-sulfhydryl chemistry that significantly increased the therapeutic efficacy of Id-KLH vaccines in three different murine B cell lymphoma models, with protection mediated by either CD8(+) T cells or antibodies. We now define in detail the methods and parameters critical for enhancing the in vivo immunogenicity of human as well as murine Id-KLH conjugate vaccines. Optimal conditions for Id sulfhydryl pre-reduction were determined, and maleimide Id-KLH conjugates maintained stability and potency even after prolonged storage. Field flow fractionation analysis of Id-KLH particle size revealed that maleimide conjugates were far more uniform in size than glutaraldehyde conjugates. Under increasingly stringent conditions, maleimide Id-KLH vaccines maintained superior efficacy over glutaraldehyde Id-KLH in treating established, disseminated murine lymphoma. More importantly, human maleimide Id-KLH conjugates were consistently superior to glutaraldehyde Id-KLH conjugates in inducing Id-specific antibody and T cell responses. The described methods should be easily adaptable to the production of clinical grade vaccines for human trials in B cell malignancies." @default.
• W2013116334 created "2016-06-24" @default.
• W2013116334 creator A5018823792 @default.
• W2013116334 creator A5027832825 @default.
• W2013116334 creator A5066129729 @default.
• W2013116334 creator A5068877548 @default.
• W2013116334 creator A5084596709 @default.
• W2013116334 creator A5087860940 @default.
• W2013116334 date "2009-01-01" @default.
• W2013116334 modified "2023-10-07" @default.
• W2013116334 title "Maleimide conjugation markedly enhances the immunogenicity of both human and murine idiotype-KLH vaccines" @default.
• W2013116334 cites W122687903 @default.
• W2013116334 cites W13898768 @default.
• W2013116334 cites W1483682701 @default.
• W2013116334 cites W1493816460 @default.
• W2013116334 cites W1512178367 @default.
• W2013116334 cites W1535389268 @default.
• W2013116334 cites W1560830856 @default.
• W2013116334 cites W1581304569 @default.
• W2013116334 cites W177504901 @default.
• W2013116334 cites W1788754252 @default.
• W2013116334 cites W1828983804 @default.
• W2013116334 cites W1903787228 @default.
• W2013116334 cites W1959650359 @default.
• W2013116334 cites W1977819914 @default.
• W2013116334 cites W1985995901 @default.
• W2013116334 cites W1991401760 @default.
• W2013116334 cites W2006370393 @default.
• W2013116334 cites W2010697453 @default.
• W2013116334 cites W2015060415 @default.
• W2013116334 cites W2019815166 @default.
• W2013116334 cites W2033018591 @default.
• W2013116334 cites W2033509201 @default.
• W2013116334 cites W2043282897 @default.
• W2013116334 cites W2055713782 @default.
• W2013116334 cites W2065381303 @default.
• W2013116334 cites W2081796018 @default.
• W2013116334 cites W2083901042 @default.
• W2013116334 cites W2086704878 @default.
• W2013116334 cites W2087138247 @default.
• W2013116334 cites W2103406969 @default.
• W2013116334 cites W2150847291 @default.
• W2013116334 cites W2151905249 @default.
• W2013116334 cites W2152471060 @default.
• W2013116334 cites W2160686798 @default.
• W2013116334 cites W2168159081 @default.
• W2013116334 cites W2337393898 @default.
• W2013116334 cites W255828724 @default.
• W2013116334 cites W2591361875 @default.
• W2013116334 doi "https://doi.org/10.1016/j.molimm.2008.10.020" @default.
• W2013116334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2768258" @default.
• W2013116334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19046770" @default.
• W2013116334 hasPublicationYear "2009" @default.
• W2013116334 type Work @default.
• W2013116334 sameAs 2013116334 @default.
• W2013116334 citedByCount "28" @default.
• W2013116334 countsByYear W20131163342012 @default.
• W2013116334 countsByYear W20131163342013 @default.
• W2013116334 countsByYear W20131163342014 @default.
• W2013116334 countsByYear W20131163342015 @default.
• W2013116334 countsByYear W20131163342016 @default.
• W2013116334 countsByYear W20131163342017 @default.
• W2013116334 countsByYear W20131163342018 @default.
• W2013116334 countsByYear W20131163342019 @default.
• W2013116334 countsByYear W20131163342021 @default.
• W2013116334 countsByYear W20131163342022 @default.
• W2013116334 crossrefType "journal-article" @default.
• W2013116334 hasAuthorship W2013116334A5018823792 @default.
• W2013116334 hasAuthorship W2013116334A5027832825 @default.
• W2013116334 hasAuthorship W2013116334A5066129729 @default.
• W2013116334 hasAuthorship W2013116334A5068877548 @default.
• W2013116334 hasAuthorship W2013116334A5084596709 @default.
• W2013116334 hasAuthorship W2013116334A5087860940 @default.
• W2013116334 hasBestOaLocation W20131163342 @default.
• W2013116334 hasConcept C134306372 @default.
• W2013116334 hasConcept C147483822 @default.
• W2013116334 hasConcept C159654299 @default.
• W2013116334 hasConcept C185592680 @default.
• W2013116334 hasConcept C188027245 @default.
• W2013116334 hasConcept C197336794 @default.
• W2013116334 hasConcept C203014093 @default.
• W2013116334 hasConcept C2776727803 @default.
• W2013116334 hasConcept C2777529624 @default.
• W2013116334 hasConcept C2779583294 @default.
• W2013116334 hasConcept C2780105360 @default.
• W2013116334 hasConcept C2780868878 @default.
• W2013116334 hasConcept C33923547 @default.
• W2013116334 hasConcept C43617362 @default.
• W2013116334 hasConcept C86803240 @default.
• W2013116334 hasConcept C8891405 @default.
• W2013116334 hasConceptScore W2013116334C134306372 @default.
• W2013116334 hasConceptScore W2013116334C147483822 @default.
• W2013116334 hasConceptScore W2013116334C159654299 @default.
• W2013116334 hasConceptScore W2013116334C185592680 @default.
• W2013116334 hasConceptScore W2013116334C188027245 @default.
• W2013116334 hasConceptScore W2013116334C197336794 @default.
• W2013116334 hasConceptScore W2013116334C203014093 @default.
• W2013116334 hasConceptScore W2013116334C2776727803 @default.

• next