FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013116510> ?p ?o ?g. }

• W2013116510 endingPage "38" @default.
• W2013116510 startingPage "32" @default.
• W2013116510 abstract "Preclinical research suggests that the clinically approved magnetic resonance imaging contrast agent mangafodipir may protect against adverse events (AEs) caused by chemotherapy, without interfering negatively with the anticancer efficacy. The present translational study tested if pretreatment with mangafodipir lowers AEs during curative (adjuvant) FOLFOX6 chemotherapy in stage III colon cancer (Dukes' C). The study was originally scheduled to include 20 patients, but because of the unforeseen withdrawal of mangafodipir from the market, the study had to be closed after 14 patients had been included. The withdrawal of mangafodipir was purely based on commercial considerations from the producer and not on any safety concerns. The patients were treated throughout the first 3 of 12 scheduled cycles. Patients were randomized to a 5-minute infusion of either mangafodipir or placebo (7 in each group). AEs were evaluated according to the National Cancer Institute's (NCI) Common Terminology Criteria for Adverse Events and the Sanofi-NCI criteria. The primary end points were neutropenia and neurosensory toxicity. There were four AEs of grade 3 (severe) and one AE of grade 4 (life threatening) in four patients in the placebo group, whereas there were none in the mangafodipir group (P < .05). Of the grade 3 and 4 events, two were neutropenia and one was neurosensory toxicity. Furthermore, white blood cell count was statistically, significantly higher in the mangafodipir group than in the placebo group (P < .01) after treatment with FOLFOX. This small feasibility study seems to confirm what has been demonstrated preclinically, namely, that pretreatment with mangafodipir lowers AEs during adjuvant 5-fluorouracil plus oxaliplatin-based chemotherapy in colon cancer patients." @default.
• W2013116510 created "2016-06-24" @default.
• W2013116510 creator A5009608417 @default.
• W2013116510 creator A5017535283 @default.
• W2013116510 creator A5034325269 @default.
• W2013116510 creator A5060579850 @default.
• W2013116510 creator A5062287073 @default.
• W2013116510 creator A5067539275 @default.
• W2013116510 date "2012-02-01" @default.
• W2013116510 modified "2023-09-26" @default.
• W2013116510 title "First Clinical Experience with the Magnetic Resonance Imaging Contrast Agent and Superoxide Dismutase Mimetic Mangafodipir as an Adjunct in Cancer Chemotherapy—A Translational Study" @default.
• W2013116510 cites W1804059878 @default.
• W2013116510 cites W1990003678 @default.
• W2013116510 cites W2011033166 @default.
• W2013116510 cites W2039626545 @default.
• W2013116510 cites W2044337309 @default.
• W2013116510 cites W2050234119 @default.
• W2013116510 cites W2053926200 @default.
• W2013116510 cites W2057975842 @default.
• W2013116510 cites W2063827414 @default.
• W2013116510 cites W2070964623 @default.
• W2013116510 cites W2103891066 @default.
• W2013116510 cites W2150759929 @default.
• W2013116510 cites W2152205973 @default.
• W2013116510 cites W2154188825 @default.
• W2013116510 cites W2161339168 @default.
• W2013116510 cites W2164194457 @default.
• W2013116510 cites W2171232394 @default.
• W2013116510 cites W2171740867 @default.
• W2013116510 cites W2327230031 @default.
• W2013116510 cites W2950567082 @default.
• W2013116510 doi "https://doi.org/10.1593/tlo.11277" @default.
• W2013116510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3281413" @default.
• W2013116510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22348174" @default.
• W2013116510 hasPublicationYear "2012" @default.
• W2013116510 type Work @default.
• W2013116510 sameAs 2013116510 @default.
• W2013116510 citedByCount "20" @default.
• W2013116510 countsByYear W20131165102012 @default.
• W2013116510 countsByYear W20131165102013 @default.
• W2013116510 countsByYear W20131165102015 @default.
• W2013116510 countsByYear W20131165102016 @default.
• W2013116510 countsByYear W20131165102017 @default.
• W2013116510 countsByYear W20131165102018 @default.
• W2013116510 countsByYear W20131165102019 @default.
• W2013116510 countsByYear W20131165102020 @default.
• W2013116510 countsByYear W20131165102021 @default.
• W2013116510 countsByYear W20131165102022 @default.
• W2013116510 countsByYear W20131165102023 @default.
• W2013116510 crossrefType "journal-article" @default.
• W2013116510 hasAuthorship W2013116510A5009608417 @default.
• W2013116510 hasAuthorship W2013116510A5017535283 @default.
• W2013116510 hasAuthorship W2013116510A5034325269 @default.
• W2013116510 hasAuthorship W2013116510A5060579850 @default.
• W2013116510 hasAuthorship W2013116510A5062287073 @default.
• W2013116510 hasAuthorship W2013116510A5067539275 @default.
• W2013116510 hasBestOaLocation W20131165101 @default.
• W2013116510 hasConcept C121608353 @default.
• W2013116510 hasConcept C126322002 @default.
• W2013116510 hasConcept C126838900 @default.
• W2013116510 hasConcept C142724271 @default.
• W2013116510 hasConcept C143409427 @default.
• W2013116510 hasConcept C197934379 @default.
• W2013116510 hasConcept C204787440 @default.
• W2013116510 hasConcept C27081682 @default.
• W2013116510 hasConcept C2776694085 @default.
• W2013116510 hasConcept C2777063308 @default.
• W2013116510 hasConcept C2777793932 @default.
• W2013116510 hasConcept C2777863537 @default.
• W2013116510 hasConcept C42219234 @default.
• W2013116510 hasConcept C71924100 @default.
• W2013116510 hasConceptScore W2013116510C121608353 @default.
• W2013116510 hasConceptScore W2013116510C126322002 @default.
• W2013116510 hasConceptScore W2013116510C126838900 @default.
• W2013116510 hasConceptScore W2013116510C142724271 @default.
• W2013116510 hasConceptScore W2013116510C143409427 @default.
• W2013116510 hasConceptScore W2013116510C197934379 @default.
• W2013116510 hasConceptScore W2013116510C204787440 @default.
• W2013116510 hasConceptScore W2013116510C27081682 @default.
• W2013116510 hasConceptScore W2013116510C2776694085 @default.
• W2013116510 hasConceptScore W2013116510C2777063308 @default.
• W2013116510 hasConceptScore W2013116510C2777793932 @default.
• W2013116510 hasConceptScore W2013116510C2777863537 @default.
• W2013116510 hasConceptScore W2013116510C42219234 @default.
• W2013116510 hasConceptScore W2013116510C71924100 @default.
• W2013116510 hasIssue "1" @default.
• W2013116510 hasLocation W20131165101 @default.
• W2013116510 hasLocation W20131165102 @default.
• W2013116510 hasLocation W20131165103 @default.
• W2013116510 hasLocation W20131165104 @default.
• W2013116510 hasLocation W20131165105 @default.
• W2013116510 hasOpenAccess W2013116510 @default.
• W2013116510 hasPrimaryLocation W20131165101 @default.
• W2013116510 hasRelatedWork W2064879719 @default.
• W2013116510 hasRelatedWork W2085830368 @default.
• W2013116510 hasRelatedWork W2349999257 @default.
• W2013116510 hasRelatedWork W2412903152 @default.
• W2013116510 hasRelatedWork W2897627387 @default.

• next