Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013128105> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2013128105 endingPage "107" @default.
- W2013128105 startingPage "103" @default.
- W2013128105 abstract "Heparin accelerates plasminogen activation by tissue type plasminogen activator (t-PA). Previous investigators have postulated that heparin administration during t-PA therapy might lead to enhanced fibrinogenolysis. In this paper, important coagulation parameters from a randomised trial of early versus delayed heparin administration, during t-PA therapy for acute myocardial infarction, were analysed. In contrast to the prediction, the late heparin group had significantly greater fibrinogen depletion (nadir fibrinogen 1.06±0.65 g/1 vs 1.46±0.61 g/l, p=0.0001) and higher fibrinogen degradation products (peak FBDP 675.9±785.3 μg/ml vs 299.7±543.5 μg/ml, p=0.0001). A possible mechanism for these findings is discussed. It has previously been demonstrated that heparin and FBDP are competitive activators of plasminogen activation by t-PA. It has also been shown that the stimulation of plasminogen activation by FBDP contributes substantially to fibrinogenolysis by t-PA. Thus, heparin may reduce fibrinogenolysis by interfering with the stimulation of plasminogen activation by FBDP." @default.
- W2013128105 created "2016-06-24" @default.
- W2013128105 creator A5015612883 @default.
- W2013128105 creator A5059367338 @default.
- W2013128105 creator A5060829829 @default.
- W2013128105 creator A5084515381 @default.
- W2013128105 creator A5089031635 @default.
- W2013128105 date "1993-03-01" @default.
- W2013128105 modified "2023-09-25" @default.
- W2013128105 title "Effect of heparin administration on fibrinogenolysis during thrombolytic therapy with tissue plasminogen activator for acute myocardial infarction" @default.
- W2013128105 cites W1487132270 @default.
- W2013128105 cites W1561981866 @default.
- W2013128105 cites W1585478607 @default.
- W2013128105 cites W1977967610 @default.
- W2013128105 cites W1978039741 @default.
- W2013128105 cites W1989582579 @default.
- W2013128105 cites W1990682178 @default.
- W2013128105 cites W2010932524 @default.
- W2013128105 cites W2022760394 @default.
- W2013128105 cites W2024779567 @default.
- W2013128105 cites W2042133127 @default.
- W2013128105 cites W2047104203 @default.
- W2013128105 cites W2059543787 @default.
- W2013128105 cites W2068261686 @default.
- W2013128105 cites W2093322042 @default.
- W2013128105 cites W2160883455 @default.
- W2013128105 cites W2317286599 @default.
- W2013128105 cites W2337057096 @default.
- W2013128105 cites W2402440509 @default.
- W2013128105 cites W2410824363 @default.
- W2013128105 cites W2416335734 @default.
- W2013128105 cites W2405844401 @default.
- W2013128105 doi "https://doi.org/10.1016/0268-9499(93)90030-y" @default.
- W2013128105 hasPublicationYear "1993" @default.
- W2013128105 type Work @default.
- W2013128105 sameAs 2013128105 @default.
- W2013128105 citedByCount "0" @default.
- W2013128105 crossrefType "journal-article" @default.
- W2013128105 hasAuthorship W2013128105A5015612883 @default.
- W2013128105 hasAuthorship W2013128105A5059367338 @default.
- W2013128105 hasAuthorship W2013128105A5060829829 @default.
- W2013128105 hasAuthorship W2013128105A5084515381 @default.
- W2013128105 hasAuthorship W2013128105A5089031635 @default.
- W2013128105 hasConcept C126322002 @default.
- W2013128105 hasConcept C164705383 @default.
- W2013128105 hasConcept C24998067 @default.
- W2013128105 hasConcept C2776336681 @default.
- W2013128105 hasConcept C2776572282 @default.
- W2013128105 hasConcept C2776825266 @default.
- W2013128105 hasConcept C2777557582 @default.
- W2013128105 hasConcept C2778382381 @default.
- W2013128105 hasConcept C2779036427 @default.
- W2013128105 hasConcept C2779679481 @default.
- W2013128105 hasConcept C2910604149 @default.
- W2013128105 hasConcept C500558357 @default.
- W2013128105 hasConcept C71924100 @default.
- W2013128105 hasConceptScore W2013128105C126322002 @default.
- W2013128105 hasConceptScore W2013128105C164705383 @default.
- W2013128105 hasConceptScore W2013128105C24998067 @default.
- W2013128105 hasConceptScore W2013128105C2776336681 @default.
- W2013128105 hasConceptScore W2013128105C2776572282 @default.
- W2013128105 hasConceptScore W2013128105C2776825266 @default.
- W2013128105 hasConceptScore W2013128105C2777557582 @default.
- W2013128105 hasConceptScore W2013128105C2778382381 @default.
- W2013128105 hasConceptScore W2013128105C2779036427 @default.
- W2013128105 hasConceptScore W2013128105C2779679481 @default.
- W2013128105 hasConceptScore W2013128105C2910604149 @default.
- W2013128105 hasConceptScore W2013128105C500558357 @default.
- W2013128105 hasConceptScore W2013128105C71924100 @default.
- W2013128105 hasIssue "2" @default.
- W2013128105 hasLocation W20131281051 @default.
- W2013128105 hasOpenAccess W2013128105 @default.
- W2013128105 hasPrimaryLocation W20131281051 @default.
- W2013128105 hasRelatedWork W1986317812 @default.
- W2013128105 hasRelatedWork W2004316159 @default.
- W2013128105 hasRelatedWork W2010171701 @default.
- W2013128105 hasRelatedWork W2011273929 @default.
- W2013128105 hasRelatedWork W2013128105 @default.
- W2013128105 hasRelatedWork W2024256489 @default.
- W2013128105 hasRelatedWork W2069460093 @default.
- W2013128105 hasRelatedWork W2083147570 @default.
- W2013128105 hasRelatedWork W2333466480 @default.
- W2013128105 hasRelatedWork W2158438728 @default.
- W2013128105 hasVolume "7" @default.
- W2013128105 isParatext "false" @default.
- W2013128105 isRetracted "false" @default.
- W2013128105 magId "2013128105" @default.
- W2013128105 workType "article" @default.