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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013128540> ?p ?o ?g. }

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• W2013128540 abstract "The anti-inflammatory effect of miyabenol A, a stilbene isolated from Vitis thunbergii, on lipopolysaccaride (LPS)-induced nitric oxide (NO) production in RAW264.7 macrophages was studied. Miyabenol A inhibited NO production (EC50: 2.7 μM) and iNOS protein and mRNA expression in a parallel concentration-dependent manner. LPS-evoked NF-κB nuclear translocation and associated IκB degradation were abrogated by miyabenol A treatment. Phosphorylations of IKKα/β, ERK1/2, JNK p38 MAPK, and Akt were observed in LPS-stimulated cells; nevertheless, miyabenol A selectively blocked IKKα/β, p38, and Akt phosphorylation. Furthermore, LPS-stimulated IKKα/β and Akt phosphorylation was abolished by p38 inhibitor SB203580. Wortmannin (a PI3K inhibitor) also attenuated LPS-induced IKKα/β phosphorylation, although to a less extent than SB203580, but failed to affect p38 phosphorylation. These observations suggested that PI3K/Akt might lie downstream of p38 MAPK to coregulate LPS-induced IKKα/β phosphorylation. Taken together, miyabenol A acted via interfering with p38 MAPK-related signal pathways to down-regulate IKK/IκB activation and NO production." @default.
• W2013128540 created "2016-06-24" @default.
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• W2013128540 date "2008-09-11" @default.
• W2013128540 modified "2023-10-16" @default.
• W2013128540 title "Miyabenol A Inhibits LPS-Induced NO Production via IKK/IκB Inactivation in RAW 264.7 Macrophages: Possible Involvement of the p38 and PI3K Pathways" @default.
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• W2013128540 doi "https://doi.org/10.1021/jf8019369" @default.
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