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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013129100> ?p ?o ?g. }

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• W2013129100 abstract "The anti-estrogen drug tamoxifen (TMX) was found to act as a strong inhibitor of purified neuronal nitric oxide synthase (nNOS) (IC50 = 2 +/- 0.5 microM), whereas it was inactive toward inducible macrophage NOS (IC50 > 100 microM). TMX affected the activation of NOS by calmodulin, as it not only inhibited L-arginine oxidation to nitric oxide and L-citrulline but also NADPH oxidation and calmodulin-dependent cytochrome c reduction catalyzed by nNOS. These results suggest that TMX could exert some of its biological effects by interfering with constitutive NOS-dependent formation of nitric oxide and/or superoxide ion in various tissues." @default.
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• W2013129100 date "1997-11-01" @default.
• W2013129100 modified "2023-10-13" @default.
• W2013129100 title "Strong Inhibition of Neuronal Nitric Oxide Synthase by the Calmodulin Antagonist and Anti-Estrogen Drug Tamoxifen" @default.
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• W2013129100 doi "https://doi.org/10.1016/s0006-2952(97)00316-x" @default.
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