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• W2013130564 abstract "The occurrence of TrkB in the murine thymus (15-day and 3-month old) was investigated by Northern blot, Western blot and immunohistochemistry. Furthermore, the thymus of 15-day-old mice carrying a non-functional mutation on trkB was analyzed. Both trkB mRNA and 145 kDa TrkB protein were detected. In addition, isolated lymphocytes and stromal cells also expressed this protein. The thymus of homozygous functionally TrkB-deficient animals showed structural and ultrastructural changes consistent with massive death of cortical lymphocytes, confirmed with TUNEL. Present results suggest a role for TrkB in maintaining the survival or preventing massive death of lymphocytes in the mammalian thymus." @default.
• W2013130564 created "2016-06-24" @default.
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• W2013130564 date "2002-08-01" @default.
• W2013130564 modified "2023-10-18" @default.
• W2013130564 title "Massive lymphocyte apoptosis in the thymus of functionally deficient TrkB mice" @default.
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• W2013130564 doi "https://doi.org/10.1016/s0165-5728(02)00166-2" @default.
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