FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013133683> ?p ?o ?g. }

• W2013133683 endingPage "989" @default.
• W2013133683 startingPage "989" @default.
• W2013133683 abstract "<h3>Background</h3> Despite the declining use of theophylline, episodes of intoxication continue to occur, producing seizures, arrhythmias, and death. <h3>Objectives</h3> To further characterize major toxic effects and to examine the efficacy of existing interventions. <h3>Methods</h3> We conducted a longitudinal cohort study of patients with theophylline overdose. For a 125-month period, all patients referred to the Massachusetts Poison Control System in Boston with a serum theophylline concentration of 167 µmol/L (≥30 µg/mL) or more were followed up prospectively. Recommended management by the poison center was uniform and protocol based. <h3>Results</h3> Three hundred fifty-six patients were enrolled. Mean age was 34.5 years (range, 3 days to 98 years). Mean peak serum theophylline concentration was 336 µmol/L (60 µg/mL) (range, 167-1360 µmol/L [30-245 µg/mL]). One hundred sixty-two patients (45.5%) had acute, 144 (40.4%) had chronic, and 50 (14.0%) had acute-on-therapeutic poisoning. Seventy-four patients (20.8%) developed cardiac arrhythmias, and 29 (8.2%) developed seizures. Fifteen patients (4.2%) died, 11 (73%) of whom had chronic overmedication. Arrhythmias were significantly more common after chronic overmedication than after acute intoxication (35% vs 10%; odds ratio, 4.97; 95% confidence interval, 2.68-9.23;<i>P</i><.001). Eight percent of patients with chronic overmedication died compared with 2.5% of those with acute intoxication (odds ratio, 3.20; 95% confidence interval, 1.01-10.39;<i>P</i>=.04). There was no significant difference in the rate of major toxic effects (25.9% vs 30.0%) or death (4.6% vs 3.7%) among patients referred from 1986 to 1991 and from 1992 to 1996. <h3>Conclusions</h3> Theophylline intoxication results in substantial morbidity and mortality, particularly in those with chronic overmedication. Treatment strategies fail to improve clinical outcome. With safer alternative options available, the current indications for theophylline should be rigorously evaluated with a goal toward minimal use of this agent." @default.
• W2013133683 created "2016-06-24" @default.
• W2013133683 creator A5017890602 @default.
• W2013133683 date "1999-05-10" @default.
• W2013133683 modified "2023-10-16" @default.
• W2013133683 title "Life-Threatening Events After Theophylline Overdose" @default.
• W2013133683 cites W1602223034 @default.
• W2013133683 cites W1605599991 @default.
• W2013133683 cites W1650373763 @default.
• W2013133683 cites W1718164771 @default.
• W2013133683 cites W1926381310 @default.
• W2013133683 cites W1969649940 @default.
• W2013133683 cites W1999350361 @default.
• W2013133683 cites W2002155796 @default.
• W2013133683 cites W2003639352 @default.
• W2013133683 cites W2010077004 @default.
• W2013133683 cites W2013117731 @default.
• W2013133683 cites W2013648504 @default.
• W2013133683 cites W2014420443 @default.
• W2013133683 cites W2019826788 @default.
• W2013133683 cites W2022935295 @default.
• W2013133683 cites W2028377811 @default.
• W2013133683 cites W2028759431 @default.
• W2013133683 cites W2032499666 @default.
• W2013133683 cites W2035241870 @default.
• W2013133683 cites W2041484251 @default.
• W2013133683 cites W2042587883 @default.
• W2013133683 cites W2049611975 @default.
• W2013133683 cites W2056225232 @default.
• W2013133683 cites W2060573907 @default.
• W2013133683 cites W2075175114 @default.
• W2013133683 cites W2075273272 @default.
• W2013133683 cites W2083336724 @default.
• W2013133683 cites W2118643436 @default.
• W2013133683 cites W2144222782 @default.
• W2013133683 cites W2144444884 @default.
• W2013133683 cites W2156074663 @default.
• W2013133683 cites W2162241295 @default.
• W2013133683 cites W2163135157 @default.
• W2013133683 cites W2281759796 @default.
• W2013133683 cites W2338429321 @default.
• W2013133683 cites W2338961790 @default.
• W2013133683 cites W2417755118 @default.
• W2013133683 cites W2417866851 @default.
• W2013133683 cites W2432883229 @default.
• W2013133683 cites W2470368491 @default.
• W2013133683 cites W2564038186 @default.
• W2013133683 cites W85970147 @default.
• W2013133683 doi "https://doi.org/10.1001/archinte.159.9.989" @default.
• W2013133683 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10326941" @default.
• W2013133683 hasPublicationYear "1999" @default.
• W2013133683 type Work @default.
• W2013133683 sameAs 2013133683 @default.
• W2013133683 citedByCount "75" @default.
• W2013133683 countsByYear W20131336832012 @default.
• W2013133683 countsByYear W20131336832013 @default.
• W2013133683 countsByYear W20131336832014 @default.
• W2013133683 countsByYear W20131336832015 @default.
• W2013133683 countsByYear W20131336832016 @default.
• W2013133683 countsByYear W20131336832017 @default.
• W2013133683 countsByYear W20131336832018 @default.
• W2013133683 countsByYear W20131336832019 @default.
• W2013133683 countsByYear W20131336832020 @default.
• W2013133683 countsByYear W20131336832021 @default.
• W2013133683 countsByYear W20131336832022 @default.
• W2013133683 crossrefType "journal-article" @default.
• W2013133683 hasAuthorship W2013133683A5017890602 @default.
• W2013133683 hasConcept C126322002 @default.
• W2013133683 hasConcept C156957248 @default.
• W2013133683 hasConcept C2778095195 @default.
• W2013133683 hasConcept C42219234 @default.
• W2013133683 hasConcept C44249647 @default.
• W2013133683 hasConcept C71924100 @default.
• W2013133683 hasConcept C72563966 @default.
• W2013133683 hasConceptScore W2013133683C126322002 @default.
• W2013133683 hasConceptScore W2013133683C156957248 @default.
• W2013133683 hasConceptScore W2013133683C2778095195 @default.
• W2013133683 hasConceptScore W2013133683C42219234 @default.
• W2013133683 hasConceptScore W2013133683C44249647 @default.
• W2013133683 hasConceptScore W2013133683C71924100 @default.
• W2013133683 hasConceptScore W2013133683C72563966 @default.
• W2013133683 hasIssue "9" @default.
• W2013133683 hasLocation W20131336831 @default.
• W2013133683 hasLocation W20131336832 @default.
• W2013133683 hasOpenAccess W2013133683 @default.
• W2013133683 hasPrimaryLocation W20131336831 @default.
• W2013133683 hasRelatedWork W1982619745 @default.
• W2013133683 hasRelatedWork W1990931289 @default.
• W2013133683 hasRelatedWork W2002131985 @default.
• W2013133683 hasRelatedWork W2002325000 @default.
• W2013133683 hasRelatedWork W2047665588 @default.
• W2013133683 hasRelatedWork W2114056959 @default.
• W2013133683 hasRelatedWork W2155710199 @default.
• W2013133683 hasRelatedWork W2359723541 @default.
• W2013133683 hasRelatedWork W2603773853 @default.
• W2013133683 hasRelatedWork W4234162597 @default.
• W2013133683 hasVolume "159" @default.
• W2013133683 isParatext "false" @default.

• next