FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013134334> ?p ?o ?g. }

• W2013134334 endingPage "2522" @default.
• W2013134334 startingPage "2517" @default.
• W2013134334 abstract "Alloantigens, unlike recall antigens, activate both CD45RA+ (naive) and CD45RO+ (memory) CD4+ cells to the same extent. These T cell subsets may therefore interact with each other in response to alloantigens on transplanted grafts. We have investigated if the ability of activated CD4+CD45RA+ and CD4+CD45RO+ T cells to produce and respond to interleukin 2 (IL2) and IL4 may be involved in this interaction. After activation, both subsets up-regulate their IL2 receptor (IL2R) and IL4R expression, yet IL4 substantially enhanced the proliferation of the CD4+CD45RA+ but not of the CD4+CD45RO+ T cell subset, while IL2 increased the proliferation of CD4+CD45RO+ but not of the CD4+CD45RA+ T cells. Significantly, the CD4+CD45RA+ T cells synthesized two- to threefold more mRNA for IL2 than the CD4+CD45RO+ subset, while the CD4+CD45RO+ T cells synthesized mRNA for IL4 and interferon-γ exclusively. The addition of IL2 to alloactivated CD4+CD45RO+ T cells further up-regulated their production of all three lymphokine mRNA; in contrast, IL4 induced an increase in mRNA for IL2 in only the alloactivated CD4+CD45RA+ subset. The reciprocity in the ability of both these CD4+ T cells to synthesize and respond to IL2 and IL4 may provide a rationale for the regulation of lymphokine interactions in vivo. Furthermore, the synergy between these subsets in response to alloantigens, which was directly quantitated by co-culturing CD4+CD45RA+ and CD4+CD45RO+ cells together prior to activation, may potentiate the alloreactivity against transplanted grafts in vivo." @default.
• W2013134334 created "2016-06-24" @default.
• W2013134334 creator A5028452183 @default.
• W2013134334 creator A5034975405 @default.
• W2013134334 creator A5042128683 @default.
• W2013134334 creator A5045532145 @default.
• W2013134334 creator A5067292723 @default.
• W2013134334 creator A5067797480 @default.
• W2013134334 date "1991-10-01" @default.
• W2013134334 modified "2023-09-27" @default.
• W2013134334 title "Human CD4+CD45RO+ and CD4+CD45RA+ T cells synergize in response to alloantigens" @default.
• W2013134334 cites W1492996678 @default.
• W2013134334 cites W1496485733 @default.
• W2013134334 cites W1512580729 @default.
• W2013134334 cites W1535100951 @default.
• W2013134334 cites W1545210904 @default.
• W2013134334 cites W1553835608 @default.
• W2013134334 cites W1559971535 @default.
• W2013134334 cites W1560041852 @default.
• W2013134334 cites W1572305746 @default.
• W2013134334 cites W1816934672 @default.
• W2013134334 cites W1922102737 @default.
• W2013134334 cites W1925570476 @default.
• W2013134334 cites W1966037431 @default.
• W2013134334 cites W1972775724 @default.
• W2013134334 cites W1977461031 @default.
• W2013134334 cites W1995593914 @default.
• W2013134334 cites W1997234232 @default.
• W2013134334 cites W1999168221 @default.
• W2013134334 cites W2007049316 @default.
• W2013134334 cites W2011774716 @default.
• W2013134334 cites W2012204136 @default.
• W2013134334 cites W2037692840 @default.
• W2013134334 cites W2051108461 @default.
• W2013134334 cites W2051808553 @default.
• W2013134334 cites W2054884912 @default.
• W2013134334 cites W2069611280 @default.
• W2013134334 cites W2084348195 @default.
• W2013134334 cites W2087774304 @default.
• W2013134334 cites W2092366718 @default.
• W2013134334 cites W2093107928 @default.
• W2013134334 cites W2125650988 @default.
• W2013134334 cites W2140202337 @default.
• W2013134334 cites W2148146593 @default.
• W2013134334 cites W2164277825 @default.
• W2013134334 cites W2172466148 @default.
• W2013134334 doi "https://doi.org/10.1002/eji.1830211031" @default.
• W2013134334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1680701" @default.
• W2013134334 hasPublicationYear "1991" @default.
• W2013134334 type Work @default.
• W2013134334 sameAs 2013134334 @default.
• W2013134334 citedByCount "41" @default.
• W2013134334 countsByYear W20131343342017 @default.
• W2013134334 countsByYear W20131343342018 @default.
• W2013134334 countsByYear W20131343342020 @default.
• W2013134334 crossrefType "journal-article" @default.
• W2013134334 hasAuthorship W2013134334A5028452183 @default.
• W2013134334 hasAuthorship W2013134334A5034975405 @default.
• W2013134334 hasAuthorship W2013134334A5042128683 @default.
• W2013134334 hasAuthorship W2013134334A5045532145 @default.
• W2013134334 hasAuthorship W2013134334A5067292723 @default.
• W2013134334 hasAuthorship W2013134334A5067797480 @default.
• W2013134334 hasConcept C147483822 @default.
• W2013134334 hasConcept C153911025 @default.
• W2013134334 hasConcept C191732599 @default.
• W2013134334 hasConcept C203014093 @default.
• W2013134334 hasConcept C2776090121 @default.
• W2013134334 hasConcept C2777371288 @default.
• W2013134334 hasConcept C2778690821 @default.
• W2013134334 hasConcept C2992881475 @default.
• W2013134334 hasConcept C49382859 @default.
• W2013134334 hasConcept C79484868 @default.
• W2013134334 hasConcept C86803240 @default.
• W2013134334 hasConcept C8891405 @default.
• W2013134334 hasConcept C95444343 @default.
• W2013134334 hasConceptScore W2013134334C147483822 @default.
• W2013134334 hasConceptScore W2013134334C153911025 @default.
• W2013134334 hasConceptScore W2013134334C191732599 @default.
• W2013134334 hasConceptScore W2013134334C203014093 @default.
• W2013134334 hasConceptScore W2013134334C2776090121 @default.
• W2013134334 hasConceptScore W2013134334C2777371288 @default.
• W2013134334 hasConceptScore W2013134334C2778690821 @default.
• W2013134334 hasConceptScore W2013134334C2992881475 @default.
• W2013134334 hasConceptScore W2013134334C49382859 @default.
• W2013134334 hasConceptScore W2013134334C79484868 @default.
• W2013134334 hasConceptScore W2013134334C86803240 @default.
• W2013134334 hasConceptScore W2013134334C8891405 @default.
• W2013134334 hasConceptScore W2013134334C95444343 @default.
• W2013134334 hasIssue "10" @default.
• W2013134334 hasLocation W20131343341 @default.
• W2013134334 hasLocation W20131343342 @default.
• W2013134334 hasOpenAccess W2013134334 @default.
• W2013134334 hasPrimaryLocation W20131343341 @default.
• W2013134334 hasRelatedWork W1578279896 @default.
• W2013134334 hasRelatedWork W1845214715 @default.
• W2013134334 hasRelatedWork W1973428630 @default.
• W2013134334 hasRelatedWork W1974802009 @default.
• W2013134334 hasRelatedWork W2005065279 @default.

• next