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• W2013138568 abstract "Inducible arginine oxidation and subsequent NO production by correspondent synthase (iNOS) are important cellular answers to proinflammatory signals. Prolonged NO production has been proved in higher organisms to cause stroke or septic shock. Several classes of potent NOS inhibitors have been reported, most of them targeting the arginine binding site of the oxygenase domain. Here we disclose the SAR and the rational design of potent and selective iNOS inhibitors which may be useful as anti-inflammatory drugs." @default.
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• W2013138568 date "2011-07-01" @default.
• W2013138568 modified "2023-10-15" @default.
• W2013138568 title "Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights" @default.
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• W2013138568 doi "https://doi.org/10.1016/j.bmcl.2011.05.073" @default.
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