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- W2013140160 abstract "An improved process for the enantioselective hydrolysis of prochiral 2-aryl-2-alkyl-disubstituted diethyl malonates catalyzed by pig liver esterase (PLE) was developed. With diethyl 2-phenyl-2-methylmalonate as a model substrate, the highest enantioselectivities (96% ee; R-isomer) were achieved when carrying out the process in the presence of a suitable mixture of cosolvents (buffer-i-PrOH-t-BuOH, 8:1:1). The process also works efficiently at higher substrate concentrations. The reaction was carried out on a multi-gram preparative scale, leading to a conversion of >95%, an enantioselectivity of 96% ee, and a yield of 83% at a substrate concentration of 200 mM." @default.
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- W2013140160 date "2005-01-01" @default.
- W2013140160 modified "2023-10-16" @default.
- W2013140160 title "Improved Process for the Enantioselective Hydrolysis of Prochiral Diethyl Malonates Catalyzed by Pig Liver Esterase" @default.
- W2013140160 doi "https://doi.org/10.1055/s-2005-871548" @default.
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