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- W2013140908 abstract "To identify the source of arachidonic acid utilized for eicosanoid production, rabbit alveolar macrophages were challenged with 1.0 μM 12-0-tetradecanyylphorbol-13-acetate (TPA) or 3.8 μM Ca+2 ionophore A23187 for 3 h. Upon stimulation with TPA, a loss of [3H]arachidonic acid from phosphatidylcholine, phosphatidylethanolamine, lyso(bis)phosphatidic acid, and phosphatidylserine/phosphatidylinositol was observed. Although calcium ionophore stimulated the liberation of arachidonate solely from phosphatidylethanolamine and phosphatidylcholine, it proved to be a poor stimulus for macrophage-synthesis of eicosanoids. Our evidence suggests that degradation of phosphatidylinositol and lyso(bis)phosphatidic acid induced by TPA yields a source of arachidonate which is the preferred substrate for oxidative metabolism by the cyclooxygenase and lipoxygenase pathways." @default.
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- W2013140908 date "1985-07-01" @default.
- W2013140908 modified "2023-09-26" @default.
- W2013140908 title "Lyso(bis)phosphatidic acid: A novel source of arachidonic acid for oxidative metabolism by rabbit alveolar macrophages" @default.
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- W2013140908 doi "https://doi.org/10.1016/0006-291x(85)90487-5" @default.
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