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- W2013141331 abstract "The human polyomavirus JC (JCV) is the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). Infection by JCV is extremely common and after primary infection, JCV persists in a latent state. However, PML is a very rare disease suggesting that the virus is tightly regulated. Previously, we showed that NF-κB and C/EBPβ regulate the JCV early and late promoters via a DNA control element, KB, which also mediates the stimulatory effects of proinflammatory cytokines such as TNF-α on JCV gene expression. Other studies have implicated NFAT4 in JCV regulation. We now report that NFAT4 and NF-κB interact at the KB element to co-operatively activate both JCV early and late transcription and viral DNA replication. This interplay is inhibited by C/EBPβ and by agents that block the calcineurin/NFAT signaling pathway. The importance of these events in the regulation of JCV latency and reactivation is discussed." @default.
- W2013141331 created "2016-06-24" @default.
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- W2013141331 date "2012-10-01" @default.
- W2013141331 modified "2023-10-06" @default.
- W2013141331 title "Cooperative roles of NF-κB and NFAT4 in polyomavirus JC regulation at the KB control element" @default.
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- W2013141331 doi "https://doi.org/10.1016/j.virol.2012.06.010" @default.
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