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• W2013143466 abstract "Background: A pathogenic link between HCV infection and PCT is sutained by high frequency of antibodies against hepatitis C virus in patients with PCT. This study was designed to evaluate if molecular and structural alterations of glycoconjugates could be produced by infection with HCV or could be the results of physiopathological disorders in PCT. Methods: Seric assessment of TSA (total sialic acid), PASA (protein associated sialic acid), LASA (lipid associated sialic acid) and FSA (free sialic acid) were made for 88 patients with PCT (men aged between 35 and 86 years) divided in 3 groups:-Group A included 42 patients with PCT and chronic alcoholism;-Group B included 37 patients with PCT and chronic infection with hepatitis C virus;-Group C included 9 patients with PCT without other risk factors. The results in the three groups were compared with those in control group (Group D- that included 60 healthy adult men). Diagnose of PCT was based on clinical data, imagistic study and biological evaluation (high urinary coproporphirines, increased urinary uroporfirines, increased serum iron and changes in liver function). Results: We obtained in patients with PCT and chronic alcoholism (group A): TSA=102,6±16,4mg/dl, PASA =69,4±12,3mg/dl, LASA=28,8±6,1mg/dl and FSA=3,9±3,7.mg/dl. In patients with PCT and HCV (group B), we obtained the following values: TSA=96,7,±18,5mg/dl, PASA =73,1±14,2mg/dl, LASA=23,4±3,6mg/dl and FSA=5,06±0,9mg/dl. In patients with PCT without other risk factors (group C) we found: TSA=81,6±12,4mg/dl, PASA =66,2±4,7mg/dl, LASA=21,9±4,5mg/dl and FSA=2,33±0,55mg/dl. Glycoconjugates levels in group D were: TSA=59,8±10,2mg/dl, PASA =57,1±9,3mg/dl, LASA=17,3±2,1mg/dl and FSA=0,95±0,22mg/dl In group B we observed a positive statistical significant correlation between TSA and FSA (r=0.428, CI=0,286-0,612, p<0,05), relation that was not found in the other groups. Conclusion: Hepatitis C virus initiates or modifies sialic acid biodistribution in different compartments of the body in patients with PCT. HCV amplifies cutaneous manifestations of PCT, fact that could be explained by the metabolic deficit in uroporfirinogen decarboxylase during the viral infection." @default.
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• W2013143466 date "2012-06-01" @default.
• W2013143466 modified "2023-10-18" @default.
• W2013143466 title "Plasmatic glycoconjugates level in patients with porfiria cutanea tarda" @default.
• W2013143466 doi "https://doi.org/10.1016/j.ijid.2012.05.231" @default.
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