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- W2013147325 abstract "Tablets of three different dilution ratios, comprised of the same excipients with a constant quantity of drug, demonstrated a significant variation of the drug's dissolution behavior. A linear relationship was obtained when plotting t50%versus tablet weight. The relationship appears to have resulted from the fact that the apparent surface area of the ruptured tablet is related to the number of discrete particles formed from disintegration and deaggregation of the tablet. An increase of the compression force for the three tablets (200, 400, and 600 mg.) provided divergent results when comparing the t50% of each tablet size, and the dissolution behavior appears to be a function of the dilution factor." @default.
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- W2013147325 date "1971-03-01" @default.
- W2013147325 modified "2023-09-25" @default.
- W2013147325 title "Dissolution of Poorly Water-Soluble Drugs II: Excipient Dilution and Force of Compression Effects on Tablets of a Quinazolinone Compound" @default.
- W2013147325 cites W1968772647 @default.
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- W2013147325 doi "https://doi.org/10.1002/jps.2600600321" @default.
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