FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013148422> ?p ?o ?g. }

• W2013148422 endingPage "2429" @default.
• W2013148422 startingPage "2418" @default.
• W2013148422 abstract "Objective To elucidate the possible involvement of the nervous system in the regulation of pathophysiologic responses in patients with rheumatoid arthritis (RA), we examined the expression of peripheral nerves containing the neuropeptides calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in RA synovium and their effects on RA synovial cell functions. Methods The effects of CGRP and VIP on proinflammatory cytokine and matrix metalloproteinase (MMP) production by RA synovial cells were estimated by enzyme-linked immunosorbent assay, and their messenger RNA (mRNA) expression by reverse transcription–polymerase chain reaction (RT-PCR) using limiting dilutions of the complementary DNA. Expression of CGRP receptors (CGRPRs) and VIP receptors (VIPRs) on RA synovial cells was assessed by RT-PCR and radioreceptor assays. The functions of CGRPRs and VIPRs of the synovial cells were studied by using a CGRPR antagonist and a VIPR antagonist, respectively. Results CGRP and VIP inhibited the proliferation of, and the proinflammatory cytokine and MMP production by, RA synovial cells at the level of mRNA expression. Expression of CGRPR and VIPR on RA fibroblast-like synovial cells was confirmed by RT-PCR and radioreceptor assays. Functions of the neuropeptide receptors were inhibited by their receptor antagonists. CGRP and VIP inhibited nuclear translocation and phosphorylation of the transcription factor cAMP response element binding protein in RA synovial cells. Conclusion CGRP and VIP inhibited excessive synovial cell functions, which suggests neural regulation of inflammatory responses in patients with RA and possible clinical application of the neuropeptides." @default.
• W2013148422 created "2016-06-24" @default.
• W2013148422 creator A5004177828 @default.
• W2013148422 creator A5016686689 @default.
• W2013148422 creator A5026355605 @default.
• W2013148422 creator A5037447223 @default.
• W2013148422 creator A5047362472 @default.
• W2013148422 date "1999-11-01" @default.
• W2013148422 modified "2023-09-30" @default.
• W2013148422 title "Evidence for neural regulation of inflammatory synovial cell functions by secreting calcitonin gene-related peptide and vasoactive intestinal peptide in patients with rheumatoid arthritis" @default.
• W2013148422 cites W1498564737 @default.
• W2013148422 cites W1517315202 @default.
• W2013148422 cites W1573952482 @default.
• W2013148422 cites W1602117004 @default.
• W2013148422 cites W1603024961 @default.
• W2013148422 cites W1968426702 @default.
• W2013148422 cites W1968736314 @default.
• W2013148422 cites W1970399975 @default.
• W2013148422 cites W1970744423 @default.
• W2013148422 cites W1978641660 @default.
• W2013148422 cites W1981201346 @default.
• W2013148422 cites W1981578013 @default.
• W2013148422 cites W1983649348 @default.
• W2013148422 cites W1987327446 @default.
• W2013148422 cites W1995950711 @default.
• W2013148422 cites W1997044455 @default.
• W2013148422 cites W1999829813 @default.
• W2013148422 cites W2004624137 @default.
• W2013148422 cites W2012469825 @default.
• W2013148422 cites W2012916830 @default.
• W2013148422 cites W2013135365 @default.
• W2013148422 cites W2015631486 @default.
• W2013148422 cites W2019591295 @default.
• W2013148422 cites W2028339112 @default.
• W2013148422 cites W2029728790 @default.
• W2013148422 cites W2031159759 @default.
• W2013148422 cites W2035808396 @default.
• W2013148422 cites W2043535293 @default.
• W2013148422 cites W2053277833 @default.
• W2013148422 cites W2053466635 @default.
• W2013148422 cites W2072742112 @default.
• W2013148422 cites W2075029170 @default.
• W2013148422 cites W2079184949 @default.
• W2013148422 cites W2079831464 @default.
• W2013148422 cites W2082314126 @default.
• W2013148422 cites W2082965390 @default.
• W2013148422 cites W2084672116 @default.
• W2013148422 cites W2091187638 @default.
• W2013148422 cites W2109658199 @default.
• W2013148422 cites W2116541892 @default.
• W2013148422 cites W2117197980 @default.
• W2013148422 cites W2118488788 @default.
• W2013148422 cites W2126613335 @default.
• W2013148422 cites W2127216663 @default.
• W2013148422 cites W2127480713 @default.
• W2013148422 cites W2133692536 @default.
• W2013148422 cites W2135114701 @default.
• W2013148422 cites W2150876596 @default.
• W2013148422 cites W2152348310 @default.
• W2013148422 cites W2152848856 @default.
• W2013148422 cites W2156664829 @default.
• W2013148422 cites W2189022852 @default.
• W2013148422 cites W2339823575 @default.
• W2013148422 doi "https://doi.org/10.1002/1529-0131(199911)42:11<2418::aid-anr21>3.0.co;2-7" @default.
• W2013148422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10555038" @default.
• W2013148422 hasPublicationYear "1999" @default.
• W2013148422 type Work @default.
• W2013148422 sameAs 2013148422 @default.
• W2013148422 citedByCount "54" @default.
• W2013148422 countsByYear W20131484222012 @default.
• W2013148422 countsByYear W20131484222014 @default.
• W2013148422 countsByYear W20131484222015 @default.
• W2013148422 countsByYear W20131484222016 @default.
• W2013148422 countsByYear W20131484222017 @default.
• W2013148422 countsByYear W20131484222018 @default.
• W2013148422 countsByYear W20131484222019 @default.
• W2013148422 countsByYear W20131484222021 @default.
• W2013148422 countsByYear W20131484222022 @default.
• W2013148422 countsByYear W20131484222023 @default.
• W2013148422 crossrefType "journal-article" @default.
• W2013148422 hasAuthorship W2013148422A5004177828 @default.
• W2013148422 hasAuthorship W2013148422A5016686689 @default.
• W2013148422 hasAuthorship W2013148422A5026355605 @default.
• W2013148422 hasAuthorship W2013148422A5037447223 @default.
• W2013148422 hasAuthorship W2013148422A5047362472 @default.
• W2013148422 hasConcept C118303440 @default.
• W2013148422 hasConcept C126322002 @default.
• W2013148422 hasConcept C134018914 @default.
• W2013148422 hasConcept C163170386 @default.
• W2013148422 hasConcept C164027704 @default.
• W2013148422 hasConcept C170493617 @default.
• W2013148422 hasConcept C2776914184 @default.
• W2013148422 hasConcept C2777077863 @default.
• W2013148422 hasConcept C2777652487 @default.
• W2013148422 hasConcept C2778690821 @default.
• W2013148422 hasConcept C2779627488 @default.
• W2013148422 hasConcept C71924100 @default.
• W2013148422 hasConcept C8330315 @default.

• next