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- W2013149867 abstract "The PTEN/PI3K pathway is commonly mutated in cancer and therefore represents a therapeutic target. In order to investigate the primary phenotypes mediated by mutant PIK3CA in a controlled and patient‐relevant context, we utilized human non‐tumorigenic MCF10A parental and isogenic knock‐in cell lines that harbor a common activating PIK3CA mutation (H1047R). We found that endogenous introduction of a mutated PIK3CA allele results in a marked epithelial‐mesenchymal transition (EMT) and invasive phenotype compared to isogenic wild‐type cells. Moreover, a potent and selective inhibitor of PIK3CA (GDC‐0941) was highly effective in reversing this phenotype in 3D cell culture. Our results suggest that invasion assays and biomarkers should be used to reveal PIK3CA ‘oncogeneaddiction’ responses of pathway‐targeted agents. Citation Information: Mol Cancer Ther 2009;8(12 Suppl):C68." @default.
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- W2013149867 date "2009-12-10" @default.
- W2013149867 modified "2023-09-26" @default.
- W2013149867 title "Abstract C68: Endogenous expression of an oncogenic PI3K mutation leads to epithelial‐mesenchymal transition (EMT) and invasiveness" @default.
- W2013149867 doi "https://doi.org/10.1158/1535-7163.targ-09-c68" @default.
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