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- W2013150609 abstract "Effects of penicillin-G(PPCN) on GABA-evoked Cl− current (IGABA) were investigated in freshly dissociated frog sensory neurons by the use of the concentration-clamp technique combined with the suction-pipette method. Under conditions where the internal and external solutions allowed only Cl− permeability, PCN elicited triphasic modulation on IGABA, consisting of two modes of blockade on IGABA and a following rebound (rebound-like transient IGABA). Simultaneously applied PCN and GABA depressed IGABA immediately (phasic blockade), with the depressed IGABA slightly recovering in amplitude to achieve a stable level of blockade (tonic blockade). When a solution containing a mixture or PCN and GABA was quickly replaced by one containing GABA alone, a rebound-like transient Cl− current (IGABA) was evoked. Each component of the PCN actions on IGABA was PCN- and GABA-concentration-dependent. The reversal potential for each component of the PCN actions on GABA was close to the chloride equilibrium potential (ECl calculated using the Nernst equation. The current-voltage (I−V) relations for both the phasic and tonic blockade revealed inward rectification, while I−V curves for the control IGABA and the IR were outwardly rectified. The degree of IGABA-desensitization and the amplitude of the IR correlated well. The data suggest that partial removal of the GABAA receptor-desensitization may result in generation of the IR." @default.
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- W2013150609 date "1975-04-01" @default.
- W2013150609 modified "2023-10-18" @default.
- W2013150609 title "Action of diazepam, dibutyryl cGMP, and GABA on presynaptic nerve terminals in bullfrog sympathetic ganglia" @default.
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- W2013150609 doi "https://doi.org/10.1016/0006-8993(75)90787-8" @default.
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