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- W2013152912 abstract "How animals coordinate gene expression in response to starvation is an outstanding problem closely linked to aging, obesity, and cancer [1Baugh L.R. Demodena J. Sternberg P.W. RNA Pol II accumulates at promoters of growth genes during developmental arrest.Science. 2009; 324: 92-94Crossref PubMed Scopus (130) Google Scholar, 2Lee B.H. Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan.PLoS Genet. 2008; 4: e1000213Crossref PubMed Scopus (71) Google Scholar, 3Kenyon C.J. The genetics of ageing.Nature. 2010; 464: 504-512Crossref PubMed Scopus (1991) Google Scholar, 4Levine A.J. Puzio-Kuter A.M. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes.Science. 2010; 330: 1340-1344Crossref PubMed Scopus (940) Google Scholar, 5Lee C. Raffaghello L. Longo V.D. Starvation, detoxification, and multidrug resistance in cancer therapy.Drug Resist. Updat. 2012; 15: 114-122Abstract Full Text Full Text PDF PubMed Scopus (47) Google Scholar]. Newly hatched Caenorhabditis elegans respond to food deprivation by halting development and promoting long-term survival (L1 diapause), thereby providing an excellent model for the study of starvation response [2Lee B.H. Ashrafi K. A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan.PLoS Genet. 2008; 4: e1000213Crossref PubMed Scopus (71) Google Scholar, 6Baugh L.R. Sternberg P.W. DAF-16/FOXO regulates transcription of cki-1/Cip/Kip and repression of lin-4 during C. elegans L1 arrest.Curr. Biol. 2006; 16: 780-785Abstract Full Text Full Text PDF PubMed Scopus (161) Google Scholar, 7Kang C. Avery L. Systemic regulation of starvation response in Caenorhabditis elegans.Genes Dev. 2009; 23: 12-17Crossref PubMed Scopus (46) Google Scholar]. Through a genetic search, we have discovered that the tumor suppressor Rb critically promotes survival during L1 diapause and most likely does so by regulating the expression of genes in both insulin-IGF-1 signaling (IIS)-dependent and -independent pathways mainly in neurons and the intestine. Global gene expression analyses suggested that Rb maintains the “starvation-induced” transcriptome and represses the “refeeding–induced” transcriptome, including the repression of many pathogen-, toxin-, and oxidative-stress-inducible and metabolic genes, as well as the activation of many other stress-resistant genes, mitochondrial respiratory chain genes, and potential IIS receptor antagonists. Notably, the majority of genes dysregulated in starved L1 Rb(−) animals were not found to be dysregulated in fed conditions. Altogether, these findings identify Rb as a critical regulator of the starvation response and suggest a link between functions of tumor suppressors and starvation survival. These results may provide mechanistic insights into why cancer cells are often hypersensitive to starvation treatment." @default.
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- W2013152912 date "2013-06-01" @default.
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- W2013152912 title "The Tumor Suppressor Rb Critically Regulates Starvation-Induced Stress Response in C. elegans" @default.
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- W2013152912 doi "https://doi.org/10.1016/j.cub.2013.04.046" @default.
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