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• W2013154269 abstract "The toxicities of chlordecone (CD), mirex (M) and photomirex (PM) were compared in the male mouse after daily oral administration of 10 mg/kg in corn oil vehicle (10 ml/kg). Mortality occurred starting day 10 with M, and day 16 with PM and CD, and LT50 values were 132, 265 and 254 mg/kg, respectively. However the LT50 values of M, PM or CD were not different (range, 100–125 mg/kg) when animals were intubated with the compounds daily at 25 or 50 mg/kg. Food and water consumption and body weight were decreased after M, but PM and CD increased these parameters. Other symptoms of toxicity included severe diarrhea with M, whereas a moderate diarrhea occurred with PM and little or no diarrhea with CD. The effects of M, PM or CD on the hepatic microsomal mixed function oxidase system were compared 4 d after the administration of 10 mg/kg/d of these compounds. M and PM were equipotent, whereas CD was found to be approximately half as effective in inducing cytochrome P-450 and associated enzyme activities. CD and M caused a decrease in blood glucose levels due to enhanced oxidation, since liver glycogen levels were also reduced. CD-induced tremors could not be prevented by restoring the blood glucose level. CD levels in liver, muscle, whole brain and plasma were several-fold higher than for either M or PM. These results suggest that although structurally similar, these three analogs differ significantly in their biological effects." @default.
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• W2013154269 date "1983-01-01" @default.
• W2013154269 modified "2023-09-26" @default.
• W2013154269 title "Comparative toxicology of mirex, photomirex and chlordecone after oral administration to the mouse" @default.
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• W2013154269 doi "https://doi.org/10.1002/etc.5620020106" @default.
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