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• W2013156158 startingPage "223" @default.
• W2013156158 abstract "Rats, subjected chronically (10-12 weeks) to a variety of mild, unpredictable stressors, showed a decrease in their consumption of weak sucrose solutions; normal behavior was restored by chronic (5-9 weeks) treatment with the tricyclic antidepressant imipramine. Acute administration of the dopamine receptor antagonist pimozide or the specific dopamine D2 receptor antagonist raclopride had no effect in nonstressed animals and in vehicle-treated stressed animals, but both drugs selectively reversed the improvement of performance in imipramine-treated stressed animals. The 5HT antagonist metergoline increased sucrose consumption in all groups. The data suggest that the mechanism of action of imipramine in this model is an increase in functional activity at dopamine (DA) synapses." @default.
• W2013156158 created "2016-06-24" @default.
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• W2013156158 date "1990-08-01" @default.
• W2013156158 modified "2023-09-25" @default.
• W2013156158 title "Dopaminergic mechanism of imipramine action in an animal model of depression" @default.
• W2013156158 cites W1975545233 @default.
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• W2013156158 doi "https://doi.org/10.1016/0006-3223(90)90577-o" @default.
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