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- W2013158496 abstract "To examine changes in the serum level of hepatitis C virus RNA in acute and chronic phases of hepatitis C virus infection, we tested serial serum samples of six patients with acute hepatitis C (posttransfusion: three; sporadic: three) and 11 patients with chronic hepatitis C using a competitive reverse transcription and polymerase chain reaction assay. The internal standard consisted of known amounts of synthetic mutated RNA. No patient with acute hepatitis showed resolution during the follow-up period (24–57 weeks). In posttransfusion cases, titers of hepatitis C virus RNA (log<sub>10</sub>[hepatitis C virus RNA copies/ml serum]) rose to a high level (7.5–9.5) in the early phase of infection (4–12 weeks after the transfusions) in association with the first serum alanine aminotransferase peaks. Titers of hepatitis C virus RNA then decreased, while serum alanine aminotransferase levels fluctuated with multiple peaks. In sporadic cases, titers of hepatitis C virus RNA had already reached a high level (7.0–7.5) at the first alanine aminotransferase peaks 2–3 weeks after the clinical onset. In chronic hepatitis C virus infection, titers of hepatitis C virus RNA remained high for follow-up periods of 6–12 years in patients with chronic active hepatitis. These results indicate that the replication of hepatitis C virus rose to a high level in the early phase of infection and that a high replicative level of hepatitis C virus might be related with progression of liver disease in the chronic phase of infection." @default.
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- W2013158496 date "1994-01-01" @default.
- W2013158496 modified "2023-09-24" @default.
- W2013158496 title "Serial quantitative analysis of serum hepatitis C virus RNA level in patients with acute and chronic hepatitis C" @default.
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- W2013158496 doi "https://doi.org/10.1016/s0168-8278(05)80146-1" @default.
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