FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013159727> ?p ?o ?g. }

• W2013159727 endingPage "221" @default.
• W2013159727 startingPage "215" @default.
• W2013159727 abstract "Although a rodent carcinogen, metronidazole is widely used in humans for the treatment of infections with anaerobic organisms. Metronidazole is mutagenic for microorganisms, but has a mainly negative data base for mammals and humans. Therefore, metronidazole is generally considered as a non-genotoxic carcinogen. Only the results of two human in vivo studies would allow the classification of metronidazole as genotoxic carcinogen: (1) the induction of DNA strand breaks; and (2) the induction of chromosome aberrations in peripheral lymphocytes after metronidazole therapy. Because the classification of metronidazole as genotoxic carcinogen would imply enormous consequences with respect to its application, both studies were reinvestigated very thoroughly. The present report describes the reinvestigation of the induction of DNA strand breaks after metronidazole therapy. Each two probes of lymphocytes of metronidazole-treated patients (3×500 to 3×750 mg/day for 5–8 days) were examined separately for the appearance of DNA strand breaks before and after treatment. In total, 400 nuclei were examined per patient. Immediately before the first, and 30 min to 2 h after the last application, 2×10 ml blood per patient was sampled, transported to the laboratory at 15–20°C to make DNA repair more difficult, and examined within the next 4–7 h for DNA strand breaks. At the same time, the individual metronidazole blood plasma levels were measured. In contrast to the published reports, no induction of DNA strand breaks after metronidazole therapy could be observed in the present study. As the applied doses (15 750 mg vs. 4800 mg) and the plasma level (up to 25 μg/ml vs. not measured) of metronidazole were much higher than in the published study, the relevance of the clearly negative result is obvious. As induction of DNA strand breaks is a frequent prerequisite for genotoxicity, metronidazole should be considered as a non-genotoxic carcinogen, and not as a genotoxic carcinogen." @default.
• W2013159727 created "2016-06-24" @default.
• W2013159727 creator A5015707272 @default.
• W2013159727 creator A5042572071 @default.
• W2013159727 date "1997-12-01" @default.
• W2013159727 modified "2023-10-18" @default.
• W2013159727 title "Reinvestigation of in vivo genotoxicity studies in man. I. No induction of DNA strand breaks in peripheral lymphocytes after metronidazole therapy" @default.
• W2013159727 cites W1484760537 @default.
• W2013159727 cites W1586114810 @default.
• W2013159727 cites W1968499584 @default.
• W2013159727 cites W1973021490 @default.
• W2013159727 cites W1977263017 @default.
• W2013159727 cites W1984920703 @default.
• W2013159727 cites W1989229340 @default.
• W2013159727 cites W1991455005 @default.
• W2013159727 cites W2000345462 @default.
• W2013159727 cites W2001882472 @default.
• W2013159727 cites W2003769803 @default.
• W2013159727 cites W2023976087 @default.
• W2013159727 cites W2033436896 @default.
• W2013159727 cites W2042321624 @default.
• W2013159727 cites W2052643474 @default.
• W2013159727 cites W2053472300 @default.
• W2013159727 cites W2055064558 @default.
• W2013159727 cites W2063620981 @default.
• W2013159727 cites W2071316897 @default.
• W2013159727 cites W2076811497 @default.
• W2013159727 cites W2078101148 @default.
• W2013159727 cites W2078575280 @default.
• W2013159727 cites W2092629964 @default.
• W2013159727 cites W2102173727 @default.
• W2013159727 cites W2109638326 @default.
• W2013159727 cites W2116619966 @default.
• W2013159727 cites W2130908403 @default.
• W2013159727 cites W2134259738 @default.
• W2013159727 cites W2140612381 @default.
• W2013159727 cites W2164490838 @default.
• W2013159727 cites W2408026452 @default.
• W2013159727 doi "https://doi.org/10.1016/s1383-5718(97)00177-0" @default.
• W2013159727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9465933" @default.
• W2013159727 hasPublicationYear "1997" @default.
• W2013159727 type Work @default.
• W2013159727 sameAs 2013159727 @default.
• W2013159727 citedByCount "24" @default.
• W2013159727 countsByYear W20131597272013 @default.
• W2013159727 countsByYear W20131597272016 @default.
• W2013159727 countsByYear W20131597272021 @default.
• W2013159727 countsByYear W20131597272023 @default.
• W2013159727 crossrefType "journal-article" @default.
• W2013159727 hasAuthorship W2013159727A5015707272 @default.
• W2013159727 hasAuthorship W2013159727A5042572071 @default.
• W2013159727 hasConcept C114246631 @default.
• W2013159727 hasConcept C126322002 @default.
• W2013159727 hasConcept C143425029 @default.
• W2013159727 hasConcept C153911025 @default.
• W2013159727 hasConcept C207001950 @default.
• W2013159727 hasConcept C2777396551 @default.
• W2013159727 hasConcept C2778959862 @default.
• W2013159727 hasConcept C29730261 @default.
• W2013159727 hasConcept C501593827 @default.
• W2013159727 hasConcept C54355233 @default.
• W2013159727 hasConcept C552990157 @default.
• W2013159727 hasConcept C71924100 @default.
• W2013159727 hasConcept C86803240 @default.
• W2013159727 hasConcept C98274493 @default.
• W2013159727 hasConceptScore W2013159727C114246631 @default.
• W2013159727 hasConceptScore W2013159727C126322002 @default.
• W2013159727 hasConceptScore W2013159727C143425029 @default.
• W2013159727 hasConceptScore W2013159727C153911025 @default.
• W2013159727 hasConceptScore W2013159727C207001950 @default.
• W2013159727 hasConceptScore W2013159727C2777396551 @default.
• W2013159727 hasConceptScore W2013159727C2778959862 @default.
• W2013159727 hasConceptScore W2013159727C29730261 @default.
• W2013159727 hasConceptScore W2013159727C501593827 @default.
• W2013159727 hasConceptScore W2013159727C54355233 @default.
• W2013159727 hasConceptScore W2013159727C552990157 @default.
• W2013159727 hasConceptScore W2013159727C71924100 @default.
• W2013159727 hasConceptScore W2013159727C86803240 @default.
• W2013159727 hasConceptScore W2013159727C98274493 @default.
• W2013159727 hasIssue "2-3" @default.
• W2013159727 hasLocation W20131597271 @default.
• W2013159727 hasLocation W20131597272 @default.
• W2013159727 hasOpenAccess W2013159727 @default.
• W2013159727 hasPrimaryLocation W20131597271 @default.
• W2013159727 hasRelatedWork W1963763999 @default.
• W2013159727 hasRelatedWork W1974217384 @default.
• W2013159727 hasRelatedWork W2013159727 @default.
• W2013159727 hasRelatedWork W2022422131 @default.
• W2013159727 hasRelatedWork W2022653668 @default.
• W2013159727 hasRelatedWork W2043426707 @default.
• W2013159727 hasRelatedWork W2063887332 @default.
• W2013159727 hasRelatedWork W2086315107 @default.
• W2013159727 hasRelatedWork W2734568297 @default.
• W2013159727 hasRelatedWork W4253829212 @default.
• W2013159727 hasVolume "395" @default.
• W2013159727 isParatext "false" @default.
• W2013159727 isRetracted "false" @default.
• W2013159727 magId "2013159727" @default.

• next