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• W2013161054 abstract "Dipicolinic acid (DPA), a small molecule analogue for the pyrroloquinoline quinone (PQQ) bacterial dehydrogenase cofactor, was used to model displacement of the complexing ion, Ca(2+), by a uranium (VI) dioxo-cation, UO2(2+). Complexation of UO2(2+) with DPA through the displacement of Ca(2+) was examined with UV/visible spectroscopy, ESI (electrospray ionization)-Mass spectrometry, and density functional theory based-modeling. The UO2(2+) displacement of other biologically important metal cations (Zn(2+), Cu(2+), Ni(2+), and Fe(3+)) from DPA was also examined. Results show that UO2(2+) has a distinctly higher binding affinity (logβ = 10.2 ± 0.1) for DPA compared to that of Ca(2+) (logβ = 4.6 ± 0.1), and provide molecular level insight into the mechanism of uranium toxicity associated with the {ONO} site. These results support those of VanEngelen et al. (2011) where a key interaction between PQQ and UO2(2+) produced significant uranium toxicity in bacteria. The observed toxicity mechanism was determined to be the displacement of a Ca(2+) cation bound to the {ONO} site on PQQ and was observed even at submicromolar UO2(2+) concentrations. Here we couple experimental findings with density functional theory (DFT) calculations to investigate the electronic and structural properties that make the {ONO} site so distinctively favorable for UO2(2+) binding. This novel approach using integrated experimental and fundamental atomic based models opens the path to identify a library of potential uranium interactions with critical biological molecules." @default.
• W2013161054 created "2016-06-24" @default.
• W2013161054 creator A5017764387 @default.
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• W2013161054 date "2015-08-01" @default.
• W2013161054 modified "2023-10-01" @default.
• W2013161054 title "A molecular level mechanism for uranium (VI) toxicity through Ca2+ displacement in pyrroloquinoline quinone-dependent bacterial dehydrogenase" @default.
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• W2013161054 cites W2033576993 @default.
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• W2013161054 cites W2037554968 @default.
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• W2013161054 cites W2063459352 @default.
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• W2013161054 cites W2071784540 @default.
• W2013161054 cites W2078912320 @default.
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• W2013161054 cites W2109861722 @default.
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• W2013161054 doi "https://doi.org/10.1016/j.jinorgbio.2014.11.007" @default.
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