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• W2013165248 abstract "Alzheimer’s disease (AD) is the leading cause for dementia in the world. It is characterized by two biochemically distinct types of protein aggregates: amyloid β (A β ) peptide in the forms of parenchymal amyloid plaques and congophilic amyloid angiopathy (CAA) and aggregated tau protein in the form of intraneuronal neurofibrillary tangles (NFT). Several risk factors have been discovered that are associated with AD. The most well-known genetic risk factor for late-onset AD is apolipoprotein E4 (ApoE4) (Potter and Wisniewski (2012), and Verghese et al. (2011)). Recently, it has been reported by two groups independently that a rare functional variant (R47H) of TREM2 is associated with the late-onset risk of AD. TREM2 is expressed on myeloid cells including microglia, macrophages, and dendritic cells, as well as osteoclasts. Microglia are a major part of the innate immune system in the CNS and are also involved in stimulating adaptive immunity. Microglia express several Toll-like receptors (TLRs) and are the resident macrophages of the central nervous system (CNS). In this review, we will focus on the recent advances regarding the role of TREM2, as well as the effects of TLRs 4 and 9 on AD." @default.
• W2013165248 created "2016-06-24" @default.
• W2013165248 creator A5034849706 @default.
• W2013165248 creator A5060656369 @default.
• W2013165248 date "2013-01-01" @default.
• W2013165248 modified "2023-10-12" @default.
• W2013165248 title "The Innate Immune System in Alzheimer’s Disease" @default.
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• W2013165248 doi "https://doi.org/10.1155/2013/576383" @default.
• W2013165248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3809371" @default.
• W2013165248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24223593" @default.

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