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• W2013165456 abstract "The relationship between ventilation (E), tidal volume (VT) and frequency (f) was studied in cats under various conditions with and without intact vagus nerves. Ventilation was increased by a rebreathing technique and the respiratory pattern was altered i.a. by thermal and electrical stimulation. With intact vagi the E - VT relationship was similar to that of man (hey et al., 1966). After vagotomy the slope constant became smaller since, in this situation, only VT, but not f, increased with increasing chemical drive. The slope constant increased with increasing temperature from < 35°C and upwards due to a selective increase of f, whether the vagi were intact or cut. It is concluded that the increase in f in response to CO2 is entirely dependent on the vagal mechanisms, while the bulbopontine pacemaker mechanisms act as the f-govemor when f is selectively increased e.g. by thermal stimulation and decortication. It was confirmed that the rate of increase of inspiratory activity depends on the chemical drive but is independent of the f-determining mechanisms. VT thus depends both on the rate of volume increase and on the part of the f-govemor which determines inspiratory duration." @default.
• W2013165456 created "2016-06-24" @default.
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• W2013165456 date "1970-07-01" @default.
• W2013165456 modified "2023-10-01" @default.
• W2013165456 title "Control mechanisms determining rate and depth of respiratory movements" @default.
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• W2013165456 doi "https://doi.org/10.1016/0034-5687(70)90030-7" @default.
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