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• W2013166769 startingPage "2069" @default.
• W2013166769 abstract "The Ran pathway has been shown to have a role in spindle assembly. However, the extent of the role of the Ran pathway in mitosis in vivo is unclear. We report that perturbation of the Ran pathway disrupted multiple steps of mitosis in syncytial Drosophila embryos and uncovered new mitotic processes that are regulated by Ran. During the onset of mitosis, the Ran pathway is required for the production, organization, and targeting of centrosomally nucleated microtubules to chromosomes. However, the role of Ran is not restricted to microtubule organization, because Ran is also required for the alignment of chromosomes at the metaphase plate. In addition, the Ran pathway is required for postmetaphase events, including chromosome segregation and the assembly of the microtubule midbody. The Ran pathway mediates these mitotic events, in part, by facilitating the correct targeting of the kinase Aurora A and the kinesins KLP61F and KLP3A to spindles." @default.
• W2013166769 created "2016-06-24" @default.
• W2013166769 creator A5006443082 @default.
• W2013166769 creator A5090478650 @default.
• W2013166769 date "2006-04-01" @default.
• W2013166769 modified "2023-10-16" @default.
• W2013166769 title "Ran Is Required before Metaphase for Spindle Assembly and Chromosome Alignment and after Metaphase for Chromosome Segregation and Spindle Midbody Organization" @default.
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• W2013166769 doi "https://doi.org/10.1091/mbc.e05-10-0991" @default.
• W2013166769 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415283" @default.
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