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• W2013167867 abstract "Mucosal and systemic immune responses to a new oral cholera vaccine, consisting of the B subunit plus killed vibrios, were studied in Bangladeshi volunteers and compared with those to clinical cholera. A single peroral dose of vaccine induced a local IgA antitoxin response in intestinal-lavage fluid of seven of eight vaccinees; the response closely mimicked that of patients convalescing from cholera, and evidence of the induction of local immunologic memory was found as well. Two peroral doses were needed for stimulation of an intestinal IgA immune response to the lipopolysaccharide of Vibrio cholerae that was comparable to the response obtained after clinical cholera. This response to peroral immunization was considerably stronger than that to parenteral vaccination, although the intramuscular route gave rise to the strongest IgG antitoxin and antilipolysaccharide responses in serum. The results suggest that B subunit-whole cell vaccine, when given in at least two oral doses, may be a good candidate for use in cholera prophylaxis." @default.
• W2013167867 created "2016-06-24" @default.
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• W2013167867 date "1984-06-01" @default.
• W2013167867 modified "2023-09-24" @default.
• W2013167867 title "Mucosal Antitoxic and Antibacterial Immunity after Cholera Disease and after Immunization with a Combined B Subunit-Whole Cell Vaccine" @default.
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• W2013167867 doi "https://doi.org/10.1093/infdis/149.6.884" @default.
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