Matches in SemOpenAlex for { <https://semopenalex.org/work/W2013172006> ?p ?o ?g. }
- W2013172006 endingPage "2783" @default.
- W2013172006 startingPage "2778" @default.
- W2013172006 abstract "Peripheral noxious stimulation is known to trigger signalling cascades in neurons of the spinal cord. The response to pain and stress at the level of gene expression involves transcriptional activation of several cyclic AMP responsive genes. Here, we show induction of the CREM (cyclic-AMP responsive element modulator) gene in distinct subpopulations of spinal cord neurons upon thermal noxious stimulation. The addition of forskolin or glutamate to cultured spinal cord neurons results in the induction of the CREM isoform, ICER (Inducible cyclic- AMP Early Repressor), a powerful repressor of CAMP-induced transcription. Overexpression of ICER in cultured spinal cord neurons results in the repression of the c-fos and c-jun promoters induced by forskolin and glutamate. On this basis, we postulate that early activation of ICER in spinal cord participates in the attenuation of early gene induction following noxious stimulation." @default.
- W2013172006 created "2016-06-24" @default.
- W2013172006 creator A5019340831 @default.
- W2013172006 creator A5031364097 @default.
- W2013172006 creator A5034335838 @default.
- W2013172006 creator A5056668414 @default.
- W2013172006 creator A5060526199 @default.
- W2013172006 creator A5085671480 @default.
- W2013172006 date "1997-12-01" @default.
- W2013172006 modified "2023-10-16" @default.
- W2013172006 title "Peripheral Noxious Stimulation Induces CREM Expression in Dorsal Horn: Involvement of Glutamate" @default.
- W2013172006 cites W1495237614 @default.
- W2013172006 cites W1634437520 @default.
- W2013172006 cites W1810764863 @default.
- W2013172006 cites W1818221350 @default.
- W2013172006 cites W1821731873 @default.
- W2013172006 cites W1834905825 @default.
- W2013172006 cites W1950744654 @default.
- W2013172006 cites W1984042854 @default.
- W2013172006 cites W1986726112 @default.
- W2013172006 cites W1988568219 @default.
- W2013172006 cites W1996339709 @default.
- W2013172006 cites W2000024512 @default.
- W2013172006 cites W2001026574 @default.
- W2013172006 cites W2006254842 @default.
- W2013172006 cites W2011465521 @default.
- W2013172006 cites W2012533550 @default.
- W2013172006 cites W2021334674 @default.
- W2013172006 cites W2023472991 @default.
- W2013172006 cites W2028242823 @default.
- W2013172006 cites W2029466905 @default.
- W2013172006 cites W2033209566 @default.
- W2013172006 cites W2039236418 @default.
- W2013172006 cites W2060645936 @default.
- W2013172006 cites W2062250586 @default.
- W2013172006 cites W2066060074 @default.
- W2013172006 cites W2066871600 @default.
- W2013172006 cites W2068895469 @default.
- W2013172006 cites W2071947397 @default.
- W2013172006 cites W2076983324 @default.
- W2013172006 cites W2082558717 @default.
- W2013172006 cites W2091061257 @default.
- W2013172006 cites W2093710529 @default.
- W2013172006 cites W2094872845 @default.
- W2013172006 cites W2100747076 @default.
- W2013172006 cites W2109399660 @default.
- W2013172006 cites W2115736681 @default.
- W2013172006 cites W2123166542 @default.
- W2013172006 cites W2144206181 @default.
- W2013172006 cites W2416022039 @default.
- W2013172006 doi "https://doi.org/10.1111/j.1460-9568.1997.tb01707.x" @default.
- W2013172006 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9517483" @default.
- W2013172006 hasPublicationYear "1997" @default.
- W2013172006 type Work @default.
- W2013172006 sameAs 2013172006 @default.
- W2013172006 citedByCount "12" @default.
- W2013172006 countsByYear W20131720062013 @default.
- W2013172006 crossrefType "journal-article" @default.
- W2013172006 hasAuthorship W2013172006A5019340831 @default.
- W2013172006 hasAuthorship W2013172006A5031364097 @default.
- W2013172006 hasAuthorship W2013172006A5034335838 @default.
- W2013172006 hasAuthorship W2013172006A5056668414 @default.
- W2013172006 hasAuthorship W2013172006A5060526199 @default.
- W2013172006 hasAuthorship W2013172006A5085671480 @default.
- W2013172006 hasConcept C104211972 @default.
- W2013172006 hasConcept C104317684 @default.
- W2013172006 hasConcept C150194340 @default.
- W2013172006 hasConcept C15490471 @default.
- W2013172006 hasConcept C158448853 @default.
- W2013172006 hasConcept C169760540 @default.
- W2013172006 hasConcept C170493617 @default.
- W2013172006 hasConcept C24998067 @default.
- W2013172006 hasConcept C2779276759 @default.
- W2013172006 hasConcept C2780775167 @default.
- W2013172006 hasConcept C53345823 @default.
- W2013172006 hasConcept C54355233 @default.
- W2013172006 hasConcept C61174792 @default.
- W2013172006 hasConcept C86803240 @default.
- W2013172006 hasConcept C95444343 @default.
- W2013172006 hasConceptScore W2013172006C104211972 @default.
- W2013172006 hasConceptScore W2013172006C104317684 @default.
- W2013172006 hasConceptScore W2013172006C150194340 @default.
- W2013172006 hasConceptScore W2013172006C15490471 @default.
- W2013172006 hasConceptScore W2013172006C158448853 @default.
- W2013172006 hasConceptScore W2013172006C169760540 @default.
- W2013172006 hasConceptScore W2013172006C170493617 @default.
- W2013172006 hasConceptScore W2013172006C24998067 @default.
- W2013172006 hasConceptScore W2013172006C2779276759 @default.
- W2013172006 hasConceptScore W2013172006C2780775167 @default.
- W2013172006 hasConceptScore W2013172006C53345823 @default.
- W2013172006 hasConceptScore W2013172006C54355233 @default.
- W2013172006 hasConceptScore W2013172006C61174792 @default.
- W2013172006 hasConceptScore W2013172006C86803240 @default.
- W2013172006 hasConceptScore W2013172006C95444343 @default.
- W2013172006 hasIssue "12" @default.
- W2013172006 hasLocation W20131720061 @default.
- W2013172006 hasLocation W20131720062 @default.
- W2013172006 hasOpenAccess W2013172006 @default.