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- W2013172615 abstract "Climbing fiber deafferentation of the weanling rat was performed initially by means of intraperitoneal administration of 3-acetylpyridine (3-AP, 65 mg/kg). This dosage of 3-AP, which has been used routinely to achieve olivary ablations in the adult rat, is inappropriate for the total destruction of the inferior olivary complex in weanling rats (21–23 days). Examination of the inferior olivary complex at both the light and electron microscopic level has revealed a consistent sparing of neurons within the nucleus β, the genu of the principal nucleus and the caudal portion of the medial accessory olive following long-term (120 days) 3-AP treatment. Complete olivary ablations in weanling rats were obtained only after the injection of a higher dose of 3-AP (90 mg/kg). It would appear that immature inferior olivary neurons are less sensitive to the toxic effect of 3-AP but become increasingly susceptible to 3-AP with maturation. If the appropriate dosage of 3-AP is employed, however, it can be used reliably to produce a chemical ablation of the total climbing fiber input to the cerebellar cortex in weanling rats." @default.
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- W2013172615 date "1996-06-01" @default.
- W2013172615 modified "2023-09-26" @default.
- W2013172615 title "Neuroprotective effects of the pyrrolopyrimidine U-104067F against 3-acetylpyridin neurotoxicity" @default.
- W2013172615 doi "https://doi.org/10.1016/0924-977x(96)88215-0" @default.
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