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• W2013176885 abstract "<b>Background and Aim</b> : Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-α) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury. <b>Materials and Methods</b> : Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure. <b>Results</b> : The I/R group's TNF-α and interleukin-6 (IL-6) levels were significantly higher than those of the control (<i>P</i> = 0.010; <i>P</i> = 0.002) and I/R + TPM groups (<i>P</i> = 0.010; <i>P</i> = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (<i>P</i> = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes. <b>Conclusion</b> : Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery." @default.
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• W2013176885 date "2014-01-01" @default.
• W2013176885 modified "2023-10-03" @default.
• W2013176885 title "Topiramate ameliorates abdominal aorta cross-clamping induced liver injury in rats" @default.
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• W2013176885 doi "https://doi.org/10.4103/1319-3767.141690" @default.
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